Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Frontiers in Immunology, 2020 Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado +15 more
doaj +1 more source
Different members of the IL-1 family come out in different ways: DAMPs vs cytokines?
Frontiers in Immunology, 2013 Intercellular communications control fundamental biological processes required for the survival of multicellular organisms. Secretory proteins are among the most important messengers in this network of information.
Sonia eCarta +2 more
doaj +1 more source
Changes in serum Interleukin-33 concentration before and after treatment with pegylated interferon alfa-2a plus ribavirin in patients with chronic hepatitis C genotype 1b infection. [PDF]
, 2012 BACKGROUND: IL-33 is a novel member of the IL-1 family, which has been shown to play an important role in T helper 2 (Th2)-associated immune responses.
Cacopardo, Bruno +3 more
core +2 more sources
Evaluation of Serum IL-33, IL-5 and Trace Elements Levels among Asthmatic Patients
Journal of Pure and Applied Microbiology, 2022 The precise relationship between interleukins-33 and IL-5, as well as some trace elements and asthma, is unknown. The target of research was to compare and link the above-mentioned serological parameters in asthmatic patients and healthy controls.
Mayada Noori Iqbal +3 more
doaj +1 more source
Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease [PDF]
, 2017 IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and marked infiltration of IgG4-positive cells in multiple organs. Interleukin-33 (IL-33) is a recently described cytokine that is secreted by damaged epithelial cells, macrophages ...
Furukawa Sachiko +14 more
core +1 more source
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation
EMBO Journal, 2021 Interleukin (IL)‐33 cytokine plays a critical role in allergic diseases and cancer. IL‐33 also has a nuclear localization signal. However, the nuclear function of IL‐33 and its impact on cancer is unknown. Here, we demonstrate that nuclear IL‐33‐mediated
Jong Ho Park +6 more
semanticscholar +1 more source
IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions
Frontiers in Immunology, 2019 The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their production is particularly important
Michelle A. Williams +2 more
doaj +1 more source
IL-33 and the PKA Pathway Regulate ILC2 Populations Expressing IL-9 and ST2
Frontiers in Immunology, 2022 Type 2 Innate lymphoid cells (ILC2s) are tissue-resident immune cells activated by epithelial-derived alarmins upon tissue damage. They regulate immunity against helminth parasites and allergies by expressing type 2 immune response cytokines including IL-
Enrique Olguín-Martínez +5 more
doaj +1 more source
Full length interleukin 33 aggravates radiation-induced skin reaction [PDF]
, 2017 The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Adam, Susanne +13 more
core +3 more sources
Interleukin-31: A Pro-inflammatory Oriented Cytokine
Frontiers in Bioscience-LandmarkType 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca +3 more
doaj +1 more source