Results 81 to 90 of about 1,096,946 (288)

Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor

Frontiers in Immunology, 2021
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflammatory
James K. Fields, James K. Fields, James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Erik H. Klontz, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg   +16 more
doaj   +1 more source

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

Nature Communications, 2020
Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that the presence of macrophages and microglia impact glioblastoma tumorigenesis and prevent durable response. Herein
A. De Boeck, B. Ahn, C. D’Mello, X. Lun, Shyam V. Menon, Mana M. Alshehri, Frank Szulzewsky, Yaoqing Shen, Lubaba Khan, N. Dang, E. Reichardt, Kim Goring, Jennifer C. King, C. Grisdale, Natalie Grinshtein, D. Hambardzumyan, Karlyne M. Reilly, M. Blough, J. Cairncross, V. Yong, M. Marra, Steven J. M. Jones, D. Kaplan, K. McCoy, E. Holland, P. Bose, J. Chan, S. Robbins, D. Senger   +28 more
semanticscholar   +1 more source

Molecular Mechanisms Underlying IL-33-Mediated Inflammation in Inflammatory Bowel Disease

International Journal of Molecular Sciences, 2022
Interleukin-33 (IL-33) is a cytokine defined by its pleiotropic function, acting either as a typical extracellular cytokine or as a nuclear transcription factor. IL-33 and its receptor, suppression of tumorigenicity 2 (ST2), interact with both innate and
I. Aggeletopoulou, E. Tsounis, C. Triantos   +2 more
semanticscholar   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis

Molecules, 2021
Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
Samuel García-Arellano, Luis Alexis Hernández-Palma, Sergio Cerpa-Cruz, Gabriela Athziri Sánchez-Zuno, Melva Guadalupe Herrera-Godina, José Francisco Muñoz-Valle   +5 more
doaj   +1 more source

Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis [PDF]

, 2016
Background. Recent works have suggested a possible link between IL-33 and B-cell biology. We aimed to study in different cohorts and with an accurate ELISA assay the possible association between serum IL-33 detection and response to rituximab (RTX) in ...
A Ahmed, Alice Courties, AM Gestel van, B Stolarski, Barbara Tolusso, Bineta Ly, D Talabot-Ayer, D Xu, D Xu, E Kunisch, E Rivière, E-J Lee, Edward M. Vital, Elodie Rivière, F Rivellese, FY Liew, Gianfranco Ferraccioli, Houria Hendel Chavez, J Malcolm, J Schmitz, J Sellam, J Sellam, J Sellam, J Shen, Jérémie Sellam, M Broek van den, M Couderc, M Komai-Koma, Martin Soubrier, Maxime Dougados, NL Millar, P Martin, Paul Emery, Paul-Olivier Rouzaire, S Sattler, SK Athari, TC Theoharides, X Mariette, Xavier Mariette, Yassine Taoufik, Z Xiangyang   +40 more
core   +6 more sources

IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors

Cells, 2021
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are strategically located in different compartments of human lung, where they play a role in several inflammatory disorders and cancer. Immunoglobulin superantigens (e.g.,
Leonardo Cristinziano, R. Poto, Gjada Criscuolo, A. L. Ferrara, M. Galdiero, Luca Modestino, S. Loffredo, A. de Paulis, G. Marone, G. Spadaro, G. Varricchi   +10 more
semanticscholar   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

IL-31 and IL-33 in rheumatoid arthritis patients

Научно-практическая ревматология, 2022
Objective – to investigate clinical and diagnostic significance of IL-31 and IL-33 determination in patients with rheumatoid arthritis (RA).Material and methods. 154 patients with a reliable diagnosis of RA were examined.
N. A. Lapkina, A. A. Baranov, N. E. Abaytova, N. Yu. Levshin, O. P. Rechkina, E. A. Leontyeva, A. S. Avdeyeva, A. S. Artyukhov, E. L. Nasonov   +8 more
doaj   +1 more source

Interactions between mast cells and smooth muscle in asthma models [PDF]

, 2014
Allergic asthma is the major phenotype of asthma and is characterized by specific responses to allergens as well as airway hyperresponsiveness (AHR), inflammation and remodelling.
Sjöberg, Lisa
core   +1 more source