Results 261 to 270 of about 15,170,590 (380)

Antigen-specific B cell response regulation by IL-10-producing tolerogenic dendritic cells. [PDF]

Sci Adv
Morali K, Steuten J, Russo F, Romana Santoni de Sio F, Menage C, Consoli V, Annoni A, Iaia S, van Ham SM, Ten Brinke A, Gregori S.   +10 more
europepmc   +1 more source

Associations of IL-10 Gene Polymorphisms with Acute Myeloid Leukemia in Hunan, China

, 2013
Chenjiao Yao, Wei Du, Hai-Bing Chen, Sheng Xiao, Chenghong Wang, Zili Fan   +5 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

IL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis. [PDF]

Front Immunol
Valenzuela RA, Vega-Tapia F, Elizalde N, Flores I, Rojas FM, Goecke A, Cuitino L, Urzua CA.   +7 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition. [PDF]

Immunity
Navarro Negredo P, You J, Hauptschein M, Schroer AB, Richard DJ, Abhiraman GC, Tsai AP, Sun ED, Notarangelo G, Ramirez-Matias J, Zhou OY, Buckley MT, Malacon KE, Xu L, Sucharov J, Ramirez Lopez E, Picton L, Wyss-Coray T, Saxton RA, Fernandes RA, Villeda SA, Garcia KC, Brunet A.   +22 more
europepmc   +1 more source

Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.

Cancer Cell, 2014
B. Ruffell, Debbie Chang-Strachan, Vivien W. Chan, Alexander Rosenbusch, Alexander Rosenbusch, C. Ho, N. Pryer, D. Daniel, E. Hwang, H. Rugo, L. Coussens   +10 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Liver-directed AAV-IL-10 therapy enhances CD8⁺ T cell-mediated immunity against hepatocellular carcinoma. [PDF]

J Immunother Cancer
Lin CI, Chiu YW, Yen MS, Wang YW, Wu YH, Chuang YH.   +5 more
europepmc   +1 more source

IFN-γ and IL-2 Responses to Recombinant AlaDH against ESAT-6/CFP-10 Fusion Antigens in the Diagnosis of Latent versus Active Tuberculosis Infection.

, 2017
Bahram Movahedi, Pooneh Mokarram, Mina Hemmati, Nader Mosavari, Razie Zare, Leila Safaee Ardekani, Zohreh Mostafavi‐Pour   +6 more
openalex   +1 more source