Results 111 to 120 of about 1,415,935 (292)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis [PDF]

, 2017
Alsya J. Affandi, Sandra C. Silva‐Cardoso, Samuel García, Emmerik F A Leijten, Tessa S. van Kempen, Wioleta Marut, Joël A. G. van Roon, Timothy R. D. J. Radstake   +7 more
openalex   +1 more source

Supplementary Material for: Potential for CCR9⁺ IL-17⁺ Regulatory T Cell as a Predictor of Early Necrotizing Enterocolitis

, 2022
Li F., Hao H., Gao X., Cai Y., Jianglu Zhou, Dan Wang, Xiuman Xiao, Li S., Ma F.   +8 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

72 IL-17 stimulates B cells to secrete AT1-AA in hypertension and multi-organ tissue dysfunction during pregnancy [PDF]

, 2021
James P. Hogg, Sarah Fitzgerald, Evangeline Deer, Lorena M. Amaral, Denise C. Cornelius, James Lemon, Owen Herrock, Tarek Ibrahim, Babbette LaMarca   +8 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Effectiveness and Drug Survival of Ixekizumab and Secukinumab in Patients with Moderate to Severe Plaque Psoriasis: Real-World Data from Bucharest, Romania

Psoriasis: Targets and Therapy
Stefana Bucur,1,2 Elena-Daniela Serban,1 Bogdan Vasile Ileanu,3 Raluca Simona Costache,4,5 Alin Codrut Nicolescu,6 Traian Constantin,7,8 Daniel Octavian Costache,1,9 Maria-Magdalena Constantin1,2 1 2nd Department of Dermatology, “Carol Davila” University
Bucur S, Serban ED, Ileanu BV, Costache RS, Nicolescu AC, Constantin T, Costache DO, Constantin MM   +7 more
doaj  

Extracellular Signal-Regulated Protein Kinase Mediates Interleukin 17 (IL-17)-Induced IL-8 Secretion inHelicobacter pylori-Infected Human Gastric Epithelial Cells

, 2004
Ladislava Sebkova, Antonia Pellicanò, Giovanni Monteleone, Barbara Grazioli, Giovanni Guarnieri, Maria Imeneo, Francesco Pallone, Francesco Luzza   +7 more
openalex   +1 more source

Decreased percentage of CD4+Foxp3+TGF-β+ and increased percentage of CD4+IL-17+ cells in bronchoalveolar lavage of asthmatics [PDF]

, 2014
Adam Barczyk, Władysław Pierzchała, Gaetano Caramori, Ryszard Wiaderkiewicz, Marcin M. Kamiński, Peter J. Barnes, Ian M. Adcock   +6 more
openalex   +1 more source