Results 141 to 150 of about 76,477,355 (241)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Expression of IL-17 and IL-31 in Genital Lichen Sclerosus

reservedBackground Il Lichen sclerosus et atrophicus (LSA) è una malattia dermatologica immuno-mediata che colpisce la cute e le mucose, in particolar modo le aree genitali di femmine e maschi.
CHINELLATO, ALBERTO
core  

Temporarily induced facial eczema by IL-17 inhibitors: a case report and literature review. [PDF]

Front Allergy
Zhang T, Meng F, He J, Li C, Zhao Z.
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Harnessing glutamine-117 plasticity toward structure-based identification of triazole IL-17 inhibitors

The proinflammatory cytokine IL-17 is crucial for host defense but has also been linked to various inflammatory and autoimmune diseases. Antibody-based IL-17 inhibitors like secukinumab (Cosentyx) have demonstrated clinical success in psoriasis ...
Knoepfel, Thomas, Schlapbach, Achim (author), Rolando, Catherine (author), Nimsgern, Pierre (author), Rondeau, Jean Michel (author), Gommermann, Nina (author), Velcicky, Juraj (author), Furet, Pascal (author), Goetz, Alban (author), Bauer, Matthias R. (author), Riek, Simone (author), Scheufler, Clemens (author), Velcicky, Juraj, Meyer, Arndt (author), Lehmann, Sylvie (author), Lehmann, Hansjoerg (author), Berst, Frédéric (author), Vögtle, Markus (author), Schmutz, Patrick (author), Tichkule, Ritesh (author), Gommermann, Nina, Burkhart, Christoph (author), Knoepfel, Thomas (author), Bauer, Matthias-1   +23 more
core   +1 more source

Hepatic Safety of IL-17 Inhibitors in Psoriasis and Psoriatic Arthritis: A 12-Month Retrospective Cohort Evaluation Using the FIB-4 Index. [PDF]

Dermatol Pract Concept
Bakay U, Duran TI, Bakay OSK, Ekmekcioglu R.   +3 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Age affects drug survival rates of interleukin (IL)-17 and IL-23 inhibitors in patients with plaque psoriasis: Results from a retrospective, multicentric, multi-country, cohort study

Scarce data related to the drug survival of biologic agents in psoriasis patients aged ≥65 years is available. To evaluate the drug survival of interleukin (IL)-23 or the IL-17 inhibitors approved for the treatment of moderate-to-severe psoriasis in ...
Bruni, M., Nogueira, M., Del Alcázar-Viladomiu, E., Torres, T., Piaserico, S., Ricceri, F., Peris, K., Lazaridou, E., Romanelli, M., Vender, R., Chiricozzi, A., Lynde, C., Llamas-Velasco, M., Yeung, J., Gkalpakiotis, S., Dauden, E., Messina, F., Teixeira, L., Puig, L., Rompoti, N., Leite, L., Mufti, A., Nidegger, A., Carrascosa, J.M., Balato, A., Hugo, J., Valerio, J., Ferreira, P., Vilarrasa, E., Alessandri-Bonetti, M., Coscarella, G., Stratigos, A.J., Daponte, A.I., Prignano, F., Bastos, P.M., Di Brizzi, E.V., Conrad, C., Gisondi, P., Daponte, Athina‐Ioanna, Torres, Tiago, Carrascosa, José-Manuel, Gisondi, Paolo, Gkalpakiotis, Spyridon, Lynde, Charles, Piaserico, Stefano, Alessandri-Bonetti, Mario, Romanelli, Marco, Di , Dauden, Esteban, Stratigos, Alexander J., Llamas‐Velasco, Mar, Rompoti, Natalia, Alessandri‐Bonetti, Mario, Peris, Ketty, Nidegger, Alessia, Lazaridou, Elizabeth, Vilarrasa, Eva, Balato, Anna, Llamas-Velasco, Mar, Nogueira, Miguel, Bastos, Pedro Mendes, del Alcázar‐Viladomiu, Elena, Del Alcázar-Viladomiu, Elena, Stratigos, Alexander J, Teixeira, Laetitia, Prignano, Francesca, Vender, Ron, Messina, Francesco, Di Brizzi, Eugenia Veronica, Chiricozzi, Andrea, Brizzi, Eugenia Veronica, Ricceri, Federica, Bruni, Manfredo, Conrad, Curdin, Mufti, Asfandyar, Leite, Luiz, Valerio, Joana, Daponte, Athina-Ioanna, Puig, Luis, Yeung, Jensen, Ferreira, Paulo, Coscarella, Giulia, Hugo, Jan, Carrascosa, José‐Manuel   +83 more
core   +1 more source

Paradoxical psoriasis with IL-17 inhibitors. [PDF]

Rheumatol Adv Pract
Singla S, Luz D.
europepmc   +1 more source