FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Comparative effectiveness of IL-12/23 and IL-23 inhibitors versus JAK inhibitors in patients with inflammatory bowel disease and hidradenitis suppurativa: a real-world propensity-matched analysis. [PDF]
Crohns Colitis 360Hafez Y, Osman A, Syn WK, Shmais M.
europepmc +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora
FEBS Open Bio, EarlyView.This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi +6 more
wiley +1 more source
Targeting the IL-23 pathway in inflammatory bowel disease: from cytokine inhibition to oral IL-23 receptor blockade. [PDF]
eGastroenterologyHonap S +6 more
europepmc +1 more source
Biologic and targeted synthetic therapies in ankylosing spondylitis: a pharmacological review. [PDF]
Front PharmacolAmeer OZ +5 more
europepmc +1 more source
Current Evidence on IL-17 and IL-(12)/23 Inhibitor Safety during Pregnancy in Psoriasis: A Call for Harmonized Data Collection. [PDF]
Acta Derm VenereolBarenbrug L +5 more
europepmc +1 more source
The Latest Progress in the Application of Tofacitinib in Rheumatic Diseases--A Narrative Review. [PDF]
Drug Des Devel TherLiu B, Liu Q, Zhao X.
europepmc +1 more source
Vitiligo onset following anti-inflammatory biological therapy: a scoping review. [PDF]
Front ImmunolRomagnuolo M +5 more
europepmc +1 more source