Results 1 to 10 of about 25,065,433 (389)
The IL-2 - IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor.
Clinical Immunology, 2020 The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity ...
J. Damoiseaux
semanticscholar +4 more sources
IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy? [PDF]
OncoImmunology, 2016 The in vivo biological activity of IL-2 can be dramatically increased by complexing with anti-IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different subsets of immune cells, depending on the clone of anti-IL-2 mAb that is ...
J. Tomala, M. Kovář
semanticscholar +5 more sources
IL-2 based cancer immunotherapies: an evolving paradigm [PDF]
Frontiers in ImmunologyDiscovered over 4 decades ago in the supernatants of activated T cells, interleukin-2 (IL-2) is a potent pleiotropic cytokine involved in the regulation of immune responses.
Sushama Rokade +3 more
doaj +2 more sources
IL-2 coordinates IL-2–producing and regulatory T cell interplay [PDF]
Journal of Experimental Medicine, 2013 Regulation of IL-2–producing CD4+ T cell numbers is controlled by a quorum-sensing feedback loop as regulatory T cells sense the IL-2 produced.
Inês F. Amado +8 more
semanticscholar +7 more sources
Prospects of IL-2 in Cancer Immunotherapy [PDF]
BioMed Research International, 2018 IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce
H. Choudhry +9 more
semanticscholar +5 more sources
Optimising IL-2 for Cancer Immunotherapy [PDF]
Immune NetwThe key role of T cells in cancer immunotherapy is well established and is highlighted by the remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion and amplify anti-tumor responses. However, total or partial tumor remission following checkpoint blockade is still limited to only a few types of tumors.
Sprent J, Boyman O.
europepmc +4 more sources
Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling. [PDF]
Mol Ther, 2023 Luetkens T.
europepmc +3 more sources
The relationship between serum levels of interleukin-2 and IL-8 with circulating microRNA-10b in patients with COVID-19 [PDF]
Iranian Journal of Immunology, 2021 Background: The role of cytokine storm in the immunopathogenesis of coronavirus disease 2019 (COVID-19) has been implicated. Objective: To determine the association of microRNA (miRNA)-10b and serum levels of IL-2 and IL-8 in patients with COVID-19 ...
Zahra Bagheri-Hosseinabadi +4 more
doaj +1 more source
Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly
Noise and HealthContext: Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.
Fernanda P. Cordeiro +4 more
doaj +2 more sources
Deutsche Zeitschrift für Sportmedizin, 2023 Purpose: The COVID-19 pandemic affects society on a global scale in many ways. In Germany, various social and leisure facilities such as schools, sports clubs and gyms had to be closed due to lockdowns.
Kalski L +7 more
doaj +1 more source