Results 141 to 150 of about 25,065,433 (389)

OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+ T cells

Oncoimmunology, 2012
Adoptive therapy with chimeric antigen receptor (CAR) redirected T cells recently showed remarkable anti-tumor efficacy in early phase clinical trials; self-repression of the immune response by T-cell secreted cytokines, however, is still an issue ...
A. Hombach, Johannes Heiders, Marcel Foppe, M. Chmielewski, H. Abken   +4 more
semanticscholar   +1 more source

Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer. [PDF]

, 1987
We have produced a T cell hybridoma line by fusion of an IL-2-dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line.
Bluestone, JA, Coligan, JE, Koning, F, Shevach, EM, Stingl, G, Yokoyama, WM   +5 more
core  

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2013
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M, Smith, Katherine A
core   +2 more sources

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, Volume 599, Issue 8, Page 1159-1168, April 2025.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Delle Congruenze Binomie Rispetto ad un Modulo Primop o ad una Potenza di Esso, nel Caso in Cui $$\frac{{p - 1}}{2}$$ Sia un Numero Primo, Ovvero il Doppiod d’un Numero PrimoSia un Numero Primo, Ovvero il Doppiod d’un Numero Primo [PDF]

, 1899
Rosario A lagna
openalex   +1 more source

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells

Journal of Experimental Medicine, 1990
T cell populations derived from naive mice produce very small amounts of interleukin 4 (IL-4) in response to stimulation on anti-CD3-coated dishes. IL-4 production by such cells is mainly found among large- and intermediate-sized T cells and is dependent
G. Gros, S. Ben-Sasson, R. Seder, F. Finkelman, W. Paul   +4 more
semanticscholar   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, Volume 599, Issue 9, Page 1317-1336, May 2025.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

DYNAMICS OF IL-2 PLASMA LEVELS IN HIV PATIENTS WITH CONSIDERING DRUGS RESISTANCE

Инфекция и иммунитет, 2018
Interleukin-2 (IL-2) is one of the most important cytokines involved in the regulation of innate and adaptive immunity. Its main  immunological function is to regulate a specific (antigen-dependent)  immune response by stimulating proliferation and ...
E. S. Eliseeva, S. P. Kruglak, L. F. Sklar, E. V. Markelova, N. A. Borovskaya   +4 more
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

IMMUNOLOGICAL AND MORPHOLOGICAL PREDICTORS OF CLINICAL HETEROGENEITY OF PATIENTS WITH GRAVES' DISEASE (BASED ON RESEARCH OF THE THYROID GLAND OPERATIONAL MATERIAL)

Бюллетень сибирской медицины, 2015
Very little research is devoted to the study of communication systemic immunological changes and local immunological changes in the tissue of the thyroid in autoimmune thyrophaties.
T. V. Saprina, T. S. Prokhorenko, N. V. Ryazantseva, I. N. Vorozhtsova, S. Yu. Martynova, A. N. Dzyuman, A. P. Zima, O. S. Popov, I. A. Khlusov, K. T. Kasoyan, I. P. Shabalova   +10 more
doaj   +1 more source