Results 151 to 160 of about 116,073,120 (283)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy. [PDF]

J Exp Med
Indart AC, Lyu H, Nguyen VQ, Rosenthal W, Palvai JR, Jang SS, Chen Y, Jude K, Su L, Garcia KC, Bluestone JA, Tang Q.   +11 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis in healthy participants. [PDF]

JCI Insight
Cooney LA, Fahning M, Khoryati L, Kus A, Scheiding S, Blanchfield L, Lawrance M, Benson B, Harris KM, Baltus GA, Agarwal S, Wnek R, Scheid JF, Cunningham-Bussel K, Kim ND, Stoch SA, Visweswaraiah J, Higginson-Scott N, Kis-Toth K, Viney JL, Otipoby KL, Sampson E, Larkin B, Campbell DJ, Long SA.   +24 more
europepmc   +1 more source

IL-2 [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis. [PDF]

Brain
Georgieva ZG, Howlett SK, Rainbow DB, Coppard V, Ellis L, Jarvis LB, Williams E, Yang JHM, Sun B, Tree T, Coles AJ, Wicker LS, Jones JL.   +12 more
europepmc   +1 more source

La lingua del Guicciardini : il discorso della città e della guerra

, 2002
[Atti del Convegno internazionale di studi tenutosi a Bologna il 19 / 21 ottobre ...
Zancarini, Jean-Claude, Fournel, Jean-Louis   +1 more
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Miniaturized IL-2/anti-IL-2 immunocytokines selectively activate and support the <i>in vivo</i> persistence of regulatory T cells. [PDF]

Front Immunol
Fabilane CS, Tomala J, Zdinak PM, Chalmers BT, Stephenson AC, Ariail E, Teeley EC, Joglekar AV, Spangler JB.   +8 more
europepmc   +1 more source