Results 191 to 200 of about 2,060,350 (286)

Modulation of VEGF and IL-2 in radiation-induced brain injury: neuroprotective effects of melatonin and ascorbic acid in rats. [PDF]

J Neurooncol
Guler Avci G, Gevrek F, Colak S, Yanci A.   +3 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

<i>In vivo</i> Expansion of Regulatory T cells via an Engineered IL-2 Mutein to Suppress Autoimmune Glomerulonephritis. [PDF]

Theranostics
Kuang H, Lin CX, Huang J, Li WX, Zhu YG, Jiang N, Li Z, Li N, Li P, Jia XY, Cui Z, Zhao MH.   +11 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Elderly female CTLs maintain their initial activation and cytotoxicity independent of IL-2. [PDF]

Immun Ageing
Hof C, Angenendt A, Janku S, Jarzembowski L, Seelert K, Zöphel D, Hoth M, Lis A.   +7 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Low Dose of IL-2 Application for Graft-Versus-Host Disease Prophylaxis Following Haploidentical Stem Cell Transplantation. [PDF]

MedComm (2020)
Xu ZL, Lv M, Yu XX, Ding YY, Han TT, Fu HX, Zhang YY, Mo XD, Sun YQ, Xu LP, Zhang XH, Wang Y, Huang XJ, Zhao XY.   +13 more
europepmc   +1 more source

IL-2 receptor; IL-2 receptor β-chain (IL2RB; CD122) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

IL2Pepscan: A machine learning framework for predicting IL-2 inducing peptides and their identification across global viral proteomes. [PDF]

Sci Rep
Arora P, Abhigyan R, Periwal N, Agrawal L, Sood V, Kaur B.   +5 more
europepmc   +1 more source