Results 21 to 30 of about 25,065,433 (389)

Factors Associated with Tuberculosis Relapses Development

Туберкулез и болезни лёгких, 2022
The objective: to identify socio-demographic, clinical and laboratory factors associated with tuberculosis recurrence.Subjects and Methods. Clinical and laboratory data of 208 TB patients treated at the National Scientific Center for Phthisiopulmonology ...
A. A. Abilbayeva, A. S. Tarabayeva, I. M. Okhas, D. K. Kuashova, I. M. Khaertynova, E. A. Shuralev   +5 more
doaj   +1 more source

De novo design of potent and selective mimics of IL-2 and IL-15

Nature, 2019
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence.
Daniel‐Adriano Silva, Shawn Yu, Umut Y. Ulge, Jamie B. Spangler, K. Jude, Carlos Labao-Almeida, Lestat R. Ali, Alfredo Quijano-Rubio, Mikel Ruterbusch, Isabel Leung, Tamara Biary, Stephanie J. Crowley, E. Marcos, C. Walkey, Brian D. Weitzner, F. Pardo-Avila, J. Castellanos, L. Carter, L. Stewart, Stanley R. Riddell, M. Pepper, G. Bernardes, M. Dougan, K. C. Garcia, David Baker   +24 more
semanticscholar   +1 more source

Modulation of T cell responses by IL-2 and IL-2 complexes

Clinical and experimental rheumatology, 2015
Interleukin-2 (IL-2) is a cytokine centrally involved in the regulation of immune tolerance and activation by its effects on CD4+ T regulatory (Treg) cells and cytotoxic effector lymphocytes, respectively. Due to these properties IL-2 immunotherapy has been used, as low-dose IL-2, in the treatment of autoimmune and chronic-inflammatory disorders ...
Boyman Onur, Kolios Antonios G A, Raeber Miro E   +2 more
openaire   +4 more sources

The IL‐2/IL‐2‐Receptor Complex in the Maturation of Rat T‐Cell Progenitors [PDF]

Journal of Immunology Research, 1997
On the basis of both the interleukin‐2‐receptor (IL‐2R) α‐chain expression on 16‐day‐old fetal rat thymocytes and the occurrence of interleukin‐2 (IL‐2) mRNA‐containing cells early during rat thymus ontogeny, we have investigated the possible role of IL‐2/IL‐2R complex in rat T‐cell maturation.
Luis Alonso, Teresa Romo, Alberto Varas, Agustín G. Zapata, Eva Jiménez, Angeles Vicente   +5 more
openaire   +4 more sources

Developmental and Anatomical Patterns Of IL-2 Gene Expression in Vivo in The Murine Thymus [PDF]

, 1993
Interleukin-2 (IL-2) is a potent growth factor that mature T lymphocytes synthesize and use as a proliferation signal. Much controversy has arisen concerning whether it is used to drive the extensive proliferation of immature pre-T cells in the thymus ...
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +3 more sources

Exposure of 1800 MHz Radiofrequency with SAR 1,6 W/kg Caused a Significant Reduction in CD4+ T Cells and Release of Cytokines In-Vitro [PDF]

Iranian Journal of Immunology, 2020
Background: Although there have been many studies investigating the effects of electromagnetic fields on humans cells and tissues, the effects of radiofrequency electromagnetic fields exposure on the cells of the immune system are still controversial ...
Maimun Zulhaidah Arthamin, Anis Sulalah, Resvina -, Chomsin Sulistya Widodo, Agustina Endharti, Edi Widjajanto, Tedy Juliandhy   +6 more
doaj   +1 more source

Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer [PDF]

, 2020
Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment. Despite its limited success, so far, in treating solid cancers, it is increasingly successful, demonstrating to have a broader therapeutic potential. In this paper we develop a mathematical model to study the efficacy of engineered T cell receptor (TCR) T cell ...
arxiv   +1 more source

Revisiting IL-2: Biology and therapeutic prospects

Science immunology, 2018
Deeper insights into the biology of interleukin-2 and its receptors are leading to therapeutic strategies for selective Treg stimulation. Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell growth factor ...
A. Abbas, E. Trotta, Dimitre R Simeonov, A. Marson, J. Bluestone   +4 more
semanticscholar   +1 more source

Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice [PDF]

, 1998
In situ hybridization and immunohistochemistry were used to determine the spectrum of tissues in which interleukin-2 (IL-2) mRNA and protein are found in healthy, normal young mice.
Rothenberg, Ellen V., Yang-Snyder, Julia A.   +1 more
core   +4 more sources

Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial

Annals of the Rheumatic Diseases, 2019
Objectives Open-labelled clinical trials suggested that low-dose IL-2 might be effective in treatment of systemic lupus erythematosus (SLE). A double-blind and placebo-controlled trial is required to formally evaluate the safety and efficacy of low-dose ...
Jing He, Ruijun Zhang, M. Shao, Xiaozhen Zhao, M. Miao, Jiali Chen, Jiajia Liu, Xiaoying Zhang, Xia Zhang, Yuebo Jin, Yu Wang, Shilei Zhang, Lei Zhu, A. Jacob, R. Jia, X. You, Xue Li, Chun Li, Yunshan Zhou, Yue Yang, H. Ye, Yanying Liu, Yin Su, N. Shen, J. Alexander, Jianping Guo, J. Ambrus, Xin Lin, Di Yu, Xiaolin Sun, Zhanguo Li   +30 more
semanticscholar   +1 more source