Results 31 to 40 of about 25,065,433 (389)
Correlation of regulatory T cells in chronic lymphocytic leukemia characterized by high-affinity CD25 expression with serum IL-2 values, IGVH mutational status, Rai stage, and therapeutic lines [PDF]
Romanian Medical Journal, 2020 The impact of the importance of regulatory T cells (Treg) in chronic lymphocytic leukemia (CLL) is still controversial and no consensus has been reached on whether the effects generated by these cells are positive or negative in terms of tumor ...
Georgiana Ene +4 more
doaj +1 more source
OncoImmunology, 2020 While anti-CEA antibodies have no direct effect on CEA-positive tumors, they can be used to direct potent anti-tumor effects as an antibody-IL-2 fusion protein (immunocytokine, ICK), and at the same time reduce the toxicity of IL-2 as a single agent ...
Maciej Kujawski +14 more
doaj +1 more source
OncoImmunology, 2021 Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes +8 more
doaj +1 more source
OncoImmunology, 2021 Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, has been ascribed a role in the expansion of myeloid progenitors in acute myeloid leukemia (AML) and in promoting myeloid cell-induced suppression of lymphocyte-mediated immunity against malignant ...
Hanna Grauers Wiktorin +6 more
doaj +1 more source
Science, 2018 (IL-)2 be or not to be? Immunological T follicular helper (TFH) cells are a subpopulation of CD4+ T cells that support B cell antibody production and the establishment of B cell memory.
D. Ditoro +18 more
semanticscholar +1 more source
Deprenyl, an old drug with new anticancer potential: Mini review [PDF]
arXiv, 2021 The anticancer potential of monoamine oxidase (MAO) was observed in pre-clinical assays conducted with cell cultures and animals. L-Deprenyl (DEP) causes apoptosis in melanoma, leukemia and mammary cells. High-dose DEP has shown toxicity in mammary and pituitary cancers, as well as in monoblastic leukemia, in rats.
arxiv
Indian Journal of Dermatology, 2021 Background: Vitiligo is an acquired depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. Although the etiology of vitiligo is unknown, over the last few years, substantial data from clinical research have greatly ...
Mohammad Reza Ranjkesh +2 more
doaj +1 more source
Optimal personalized therapies in colon-cancer induced immune response using a Fokker-Planck framework [PDF]
arXiv, 2022 In this paper, a new stochastic framework to determine optimal combination therapies in colon cancer-induced immune response is presented. The dynamics of colon cancer is described through an It\"o stochastic process, whose probability density function evolution is governed by the Fokker-Planck equation.
arxiv
An essential role for IL-2 receptor in regulatory T cell function
Nature Immunology, 2016 Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells.
T. Chinen +9 more
semanticscholar +1 more source
A Requirement for IL-2/IL-2 Receptor Signaling in Intrathymic Negative Selection [PDF]
The Journal of Immunology, 2001 AbstractThe nature of the signals that influence thymocyte selection and determine the fate of CD4+8+ (double positive) thymocytes remains unclear. Cytokines produced locally in the thymus may modulate signals delivered by TCR-MHC/peptide interactions and thereby influence the fate of double-positive thymocytes. Because the IL-2/IL-2R signaling pathway
Hamid Bassiri, Simon R. Carding
openaire +3 more sources