Relationship between serum level of interleukin-2 in patients with systemic lupus erythematosus and disease activity in comparison with control group [PDF]
, 2014 Background: Despite the large number of surveys, there are not any validated biomarkers for SLE disease activity till now. This study aimed to evaluate the relationship between serum level of IL-2 in patients with SLE and disease activity in comparison ...
Sedighi, S. +3 more
core +1 more source
The cellular markers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune response [PDF]
CellR4, 2022 Objective: The peculiarity of immune response during and after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is of special interest as this may contribute to the development of an efficient diagnostic approach.
E. Kldiashvili +2 more
doaj +1 more source
Targeting IL-2: an unexpected effect in treating immunological diseases
Signal Transduction and Targeted Therapy, 2018 Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis since Treg dysfunction in both animals and humans is associated with multi-organ autoimmune and inflammatory disease.
Congxiu Ye, D. Brand, S. Zheng
semanticscholar +1 more source
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]
, 2017 IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri +8 more
core +1 more source
Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy [PDF]
, 2017 The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and ...
Fremont, Daved H +6 more
core +2 more sources
IL-2 and Beyond in Cancer Immunotherapy.
Journal of Interferon and Cytokine Research, 2018 The development of the T- and natural killer (NK) cell growth factor IL-2 has been a sentinel force ushering in the era of immunotherapy in cancer. With the advent of clinical grade recombinant IL-2 in the mid-1980s, oncologists could for the first time ...
J. Wrangle +9 more
semanticscholar +1 more source
The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2 [PDF]
, 1990 The gene encoding interleukin-2 (IL-2) contains a sequence 52 to 326 nucleotides upstream of its transcriptional initiation site that promotes transcription in T cells that have been activated by costimulation with tetradecanoyl phorbol myristyl acetate (
Baltimore, David +3 more
core +2 more sources
Mathematical Biosciences and Engineering, 2016 Understanding the global interaction dynamics between tumor and the immunesystem plays a key role in the advancement of cancer therapy.Bunimovich-Mendrazitsky et al.
K. E. Starkov +1 more
doaj +1 more source
Journal of Neuroscience, 2018 Regulatory T cells (Tregs) are known to protect against ischemic stroke. However, the low frequency of Tregs restricts their clinical utility. This study investigated whether expanding the number of Tregs in vivo with the IL-2/IL-2 antibody complex (IL-2/
Haiyue Zhang +11 more
semanticscholar +1 more source
Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]
, 1994 Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core +2 more sources