Results 311 to 320 of about 1,375,213 (331)
Some of the next articles are maybe not open access.
IL-23 promotes tumour incidence and growth
Nature, 2006Chronic inflammation has long been associated with increased incidence of malignancy and similarities in the regulatory mechanisms have been suggested for more than a century. Infiltration of innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and vasculature density are a few examples of the similarities ...
John L, Langowski +9 more
openaire +2 more sources
Inflammatory Bowel Diseases, 2010
Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response, respectively. However, recent studies have shown that in both inflammatory bowel diseases (IBD) there is also enhanced synthesis of cytokines made by a distinct subset of T ...
Sarra, M +3 more
openaire +3 more sources
Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response, respectively. However, recent studies have shown that in both inflammatory bowel diseases (IBD) there is also enhanced synthesis of cytokines made by a distinct subset of T ...
Sarra, M +3 more
openaire +3 more sources
IL‐23 in the Pathogenesis of Rheumatoid Arthritis
Scandinavian Journal of Immunology, 2010AbstractInterleukin‐23 (IL‐23) is a heterodimeric cytokine belonging to the IL‐6/IL‐12 family that plays a key role in several of autoimmune and inflammatory disorders. This family contains the 34 type I cytokine receptor chains and 27 ligands, which share structural and functional similarities, but on the other hand they display distinct roles in ...
A, Paradowska-Gorycka +3 more
openaire +2 more sources
IL-23 inhibition for chronic inflammatory disease
The LancetBiological monoclonal antibody drugs inhibit overactive cytokine signalling that drives chronic inflammatory disease in different organ systems. In the last 10 years, interleukin (IL)-23 inhibitors have attained an important position in the treatment of psoriatic skin and joint disease as well as inflammatory bowel diseases.
Vipul, Jairath +2 more
openaire +2 more sources
Differentiating IL-23 Inhibitors in Crohn’s Disease
DrugsInterleukin-23 (IL-23), a member of the IL-12 family of cytokines, plays a critical role in intestinal homeostasis and inflammation and is strongly implicated in the pathogenesis of inflammatory bowel disease (IBD). Therapies targeting the p19 subunit of IL-23 have recently expanded the therapeutic options for IBD demonstrating efficacy and safety for ...
Olga Maria Nardone +4 more
openaire +2 more sources
2013
The discovery of IL-23 and characterization of the biology governed by this cytokine has led to dramatic new insights within immunology. IL-23 is central to the pathogenesis of many immune-mediated inflammatory disorders and was shown to act via a novel IL-17-producing T helper subset, the Th17 cell.
Jonathan P. Sherlock +2 more
openaire +1 more source
The discovery of IL-23 and characterization of the biology governed by this cytokine has led to dramatic new insights within immunology. IL-23 is central to the pathogenesis of many immune-mediated inflammatory disorders and was shown to act via a novel IL-17-producing T helper subset, the Th17 cell.
Jonathan P. Sherlock +2 more
openaire +1 more source
Gums make IL-23, no professionals needed
ImmunityIL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic regulation of IL-17-associated inflammation.
openaire +2 more sources
Targeting IL-23 in autoimmunity.
Current opinion in investigational drugs (London, England : 2000), 2005Dysregulated cell-mediated immune responses may lead to chronic inflammation and autoimmune disorders. The recent discovery of the dimeric interleukin (IL)-12-related cytokine IL-23 now adds to our understanding of the fine-tuning of cellular immunity.
openaire +1 more source