Results 321 to 330 of about 1,415,739 (335)
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Serum IL-23 in asthmatic children.
Journal of biological regulators and homeostatic agents, 2012Asthma is characterized by airway inflammation that is controlled by a complex cytokine network. The Th1/Th2 imbalance has been well documented in the pathogenesis of allergic asthma. Recently, Th17 cells and regulatory T (Treg) cells have been found to participate in the pathogenesis of allergic asthma.
Ciprandi, G +9 more
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Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis
Rheumatology International, 2009The objective of this study was to investigate the expression of IL-23 and IL-17 and the influence of IL-23 on IL-17 production in ankylosing spondylitis (AS) patients. IL-23 and IL-17 levels in the serum and supernatants of cultured peripheral blood mononuclear cells (PBMCs) were determined by ELISA.
Xinwei, Wang +4 more
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The Involvement of IL-23 and the Th17 Pathway in Periodontitis
Journal of Dental Research, 2009Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in periodontal lesions and control ...
H, Ohyama +9 more
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Emerging role of IL-23 in rheumatoid arthritis
Clinical Rheumatology, 2011Dear Editor, Emerging evidence suggests that Th17 cells play a role in rheumatoid arthritis (RA) and is dependent on IL-23 for their survival and expansion [1]. Along this line, Singh et al. [2] reported that Th17 associated cytokines, particularly IL-17, IL-1β, IL-6, IL-21, IL-23, and TGF-β, in synovial fluid of reactive arthritis (ReA) and ...
Feng-Lai, Yuan +3 more
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IL-23 promotes tumour incidence and growth
Nature, 2006Chronic inflammation has long been associated with increased incidence of malignancy and similarities in the regulatory mechanisms have been suggested for more than a century. Infiltration of innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and vasculature density are a few examples of the similarities ...
John L, Langowski +9 more
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IL-12-and IL-23 in health and disease
Cytokine & Growth Factor Reviews, 2014Interleukin (IL)-12 and IL-23 play important roles in the development of experimental autoimmune disease models and numerous afflictions affecting humans. Preclinical data over the last 20 years combined with successful clinical trials has identified a clear relationship between IL-12, IL-23 and the generation of pathogenic T helper cells capable of ...
Croxford, Andrew L +2 more
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Dual Inhibition of IL-12/IL-23 and Selective Inhibition of IL-23 in Psoriasis
2018The etiology of psoriasis is unknown, although it is generally believed to be a complex T cell-mediated inflammatory disease with a genetic basis [1, 2]. CD4+ T helper cells, called T helper (Th) 17 cells, are important in the pathogenesis of psoriasis [2–5].
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IL-23 inhibition for chronic inflammatory disease
The LancetBiological monoclonal antibody drugs inhibit overactive cytokine signalling that drives chronic inflammatory disease in different organ systems. In the last 10 years, interleukin (IL)-23 inhibitors have attained an important position in the treatment of psoriatic skin and joint disease as well as inflammatory bowel diseases.
Vipul, Jairath +2 more
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