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Correction for Ota et al., Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling. [PDF]
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IL-23 and the Tumor Microenvironment
2021The tumor microenvironment (TME), which assists in the development, progression, and metastasis of malignant cells, is instrumental in virtually every step of tumor development. While a healthy TME can protect against malignancy, in an unhealthy state, it can result in aberrant cellular behavior and augment tumor progression.
Sweta, Subhadarshani +2 more
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IL‐23 in the Pathogenesis of Rheumatoid Arthritis
Scandinavian Journal of Immunology, 2010AbstractInterleukin‐23 (IL‐23) is a heterodimeric cytokine belonging to the IL‐6/IL‐12 family that plays a key role in several of autoimmune and inflammatory disorders. This family contains the 34 type I cytokine receptor chains and 27 ligands, which share structural and functional similarities, but on the other hand they display distinct roles in ...
A, Paradowska-Gorycka +3 more
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Targeting IL-23 in Crohn’s disease
Expert Review of Clinical Immunology, 2018Interleukin (IL)-23, a cytokine produced by antigen presenting cells, targets both T cells and non-T cell types with the downstream effect of enhancing inflammatory pathways. Genome-wide association studies and data from human and mouse models of intestinal inflammation support the pathogenic role of IL-23 in Crohn's disease (CD), an immune-mediated ...
Silvia, Sedda +2 more
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Targeting IL-23 in human diseases
Expert Opinion on Therapeutic Targets, 2010IL-23 is one of the most intriguing cytokine for its many immunological functions, which are the basis of its important role in host defense but also of its possible contribution to the pathogenesis of several diseases.The literature and patents about IL-23 pathway and their targeting in therapeutic potential applications. Findings published within the
D'ELIOS, MARIO MILCO +2 more
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IL-23 inhibition for the treatment of psoriatic arthritis
Expert Opinion on Biological Therapy, 2021Psoriatic arthritis (PsA) is a complex, polygenic immune-mediated disease with varying clinical presentations involving the skin, nails, entheses, and axial/peripheral skeleton.Pathophysiology of PsA with special focus on IL-23/IL-17 axis. Novel classes of targeted therapies for PsA. Pharmacologic properties, efficacy and safety of guselkumab, the only
Raagav, Mohanakrishnan +2 more
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Employing an IL-23 p19 Vaccine to Block IL-23 Ameliorates Chronic Murine Colitis
Immunotherapy, 2013Overexpression of IL-23 has been implicated in the pathogenesis of Crohn's disease. Using vaccines to block overexpressed endogenous cytokines has emerged as a new therapeutic strategy for the long-term treatment of the disease.We sought to develop peptide-based vaccines specific to IL-23 and evaluate their effects in colitis mice.The vaccine was ...
Qingdong, Guan +7 more
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IL-23 Inhibitors for Psoriasis
Current Dermatology Reports, 2018The purpose of this article is to review current understanding of the role of IL-23 in psoriasis and the available results to date on clinical trials establishing the efficacy and safety of IL-23 inhibitors for use in adults with moderate-to-severe plaque psoriasis.
Kristen M. Beck +3 more
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2013
The discovery of IL-23 and characterization of the biology governed by this cytokine has led to dramatic new insights within immunology. IL-23 is central to the pathogenesis of many immune-mediated inflammatory disorders and was shown to act via a novel IL-17-producing T helper subset, the Th17 cell.
Jonathan P. Sherlock +2 more
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The discovery of IL-23 and characterization of the biology governed by this cytokine has led to dramatic new insights within immunology. IL-23 is central to the pathogenesis of many immune-mediated inflammatory disorders and was shown to act via a novel IL-17-producing T helper subset, the Th17 cell.
Jonathan P. Sherlock +2 more
openaire +1 more source