Results 291 to 300 of about 1,415,739 (335)

Il teremoto del 23 Febbraio 1887

Bollettino della Società Geografica Italiana, 1887
Pietro Tacchini
doaj  

ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs. [PDF]

J Exp Clin Cancer Res
Talarico G, Lecchi M, Zanichelli A, Portararo P, Botti L, Cappelletti V, Costanza M, Piva A, Pratesi P, Bertolini F, Di Nicola M, Tripodo C, Cancila V, Pupa SM, Colombo MP, Chiodoni C, Verderio P, Sangaletti S.   +17 more
europepmc   +1 more source

Additional file 1 of CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions

Joel F. Cohen-Solal, Calvin S. Pohl, Sheila M. Cummings, Jeremy P. Gygi, Zhaleh Safikhani, Brigitte Bartocha, Christopher D. Buckley, Yongli Dong, K Eyerich, Samuel D. Karsen, Grace R. Lynch, Michael Macoritto, Pierre A. Morisset, Ornella Nelson, Timothy Radstake, Florian Rieder, Jocelyn Rivas, John P. Savaryn, Kathleen M. Smith, Madison Stulir, Carmin Szynal, Casey Tylek, Geertruida M. Veldman, Laura Wasserman, Susan Westmoreland, Neha Chaudhary, Matthew Staron   +26 more
openalex   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Real-World Efficacy of IL-23 Inhibitors in Psoriasis Affecting High-Impact Areas: Indirect Comparison of Tildrakizumab 200 mg, Risankizumab, and Guselkumab-IL PSO (Italian Landscape Psoriasis). [PDF]

Dermatol Ther (Heidelb)
Trovato E, Cartocci A, Gaiani F, Messina F, Mastorino L, Macagno N, Carugno A, Campoli M, Fargnoli MC, Lora V, Rossi A, Gioacchini H, Potestio L, D'Agostino GM, Maurelli M, Girolomoni G, Romanelli M, Dini V, Loconsole F, Satolli F, Pagnanelli G, Lasagni C, Michelerio A, Dragotto M, Malagoli P, Zerbinati N, Orsini D, Campanati A, Megna M, Bianchelli T, Italian Landscape Group, Costanzo A, Ribero S, Narcisi A.   +33 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Targeting the IL-23 Receptor Gene: A Promising Approach in Inflammatory Bowel Disease Treatment. [PDF]

Int J Mol Sci
Pastras P, Aggeletopoulou I, Papantoniou K, Triantos C.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Identification of an Induced Orthosteric Pocket in IL-23: A New Avenue for Non-biological Therapeutic Targeting. [PDF]

ACS Chem Biol
Lecomte FC, Joseph JS, Stalewski J, Shen Q, Arnoult E, Sridhar V, Liu M, Hu Y, Gasendo JG, Ben Arie H, Keinan N, Keidar L, Aviv I, Ruvinov E, Grandjean J, Dores-Silva PR, Mak A, Santoso B, Kim S, Shende V, Wever WJ, Mirzadegan T, Zhu Z, Fuchs B, Pinton P, Szabady R.   +25 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source