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Dual Inhibition of IL-12/IL-23 and Selective Inhibition of IL-23 in Psoriasis
2018The etiology of psoriasis is unknown, although it is generally believed to be a complex T cell-mediated inflammatory disease with a genetic basis [1, 2]. CD4+ T helper cells, called T helper (Th) 17 cells, are important in the pathogenesis of psoriasis [2–5].
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IL-23 promotes tumour incidence and growth
Nature, 2006Chronic inflammation has long been associated with increased incidence of malignancy and similarities in the regulatory mechanisms have been suggested for more than a century. Infiltration of innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and vasculature density are a few examples of the similarities ...
John L, Langowski +9 more
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IL-23 inhibitors for moderate-to-severe psoriasis
Seminars in Cutaneous Medicine and Surgery, 2018Since the identification of high levels of interleukin 23 (IL- 23) in psoriasis lesional skin, as well as finding that IL-23 was the most important source of the p40 subunit shared by IL-12 and IL-23, significant effort has been made in identifying potential new drugs that specifically block the unique IL-23 p19 subunit.
Erin, Ibler, Kenneth B, Gordon
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Targeting IL-23 for IBD: Rationale and Progress to Date
Drugs, 2023S. Vuyyuru +5 more
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IL-23 inhibition for chronic inflammatory disease
The LancetBiological monoclonal antibody drugs inhibit overactive cytokine signalling that drives chronic inflammatory disease in different organ systems. In the last 10 years, interleukin (IL)-23 inhibitors have attained an important position in the treatment of psoriatic skin and joint disease as well as inflammatory bowel diseases.
Vipul, Jairath +2 more
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Targeting IL-23 in autoimmunity.
Current opinion in investigational drugs (London, England : 2000), 2005Dysregulated cell-mediated immune responses may lead to chronic inflammation and autoimmune disorders. The recent discovery of the dimeric interleukin (IL)-12-related cytokine IL-23 now adds to our understanding of the fine-tuning of cellular immunity.
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