Results 261 to 270 of about 5,569,467 (288)

Employing an IL-23 p19 Vaccine to Block IL-23 Ameliorates Chronic Murine Colitis

Immunotherapy, 2013
Overexpression of IL-23 has been implicated in the pathogenesis of Crohn's disease. Using vaccines to block overexpressed endogenous cytokines has emerged as a new therapeutic strategy for the long-term treatment of the disease.We sought to develop peptide-based vaccines specific to IL-23 and evaluate their effects in colitis mice.The vaccine was ...
Qingdong, Guan, Helen A, Burtnick, Gefei, Qing, Carolyn R, Weiss, Allan G, Ma, Yanbing, Ma, Richard J, Warrington, Zhikang, Peng   +7 more
openaire   +2 more sources

Epithelial-derived interleukin 23 (IL-23) promotes oral mucosal immunopathology

Immunity
SUMMARY At mucosal surfaces, epithelial cells provide a structural barrier and an immune defense system. However, dysregulated epithelial responses can contribute to disease states.
Tae Sung Kim, Tomoko Ikeuchi, V. Theofilou, D. Williams, T. Greenwell-Wild, Armond June, E. E. Adade, Lu Li, L. Abusleme, N. Dutzan, Yao Yuan, L. Brenchley, N. Bouladoux, Y. Sakamachi, Robert J. Palmer, R. Iglesias-Bartolome, G. Trinchieri, S. Garantziotis, Y. Belkaid, A. Valm, Patricia I Diaz, Steven M. Holland, Niki M. Moutsopoulos   +22 more
semanticscholar   +1 more source

IL-23 Inhibitors for Psoriasis

Current Dermatology Reports, 2018
The purpose of this article is to review current understanding of the role of IL-23 in psoriasis and the available results to date on clinical trials establishing the efficacy and safety of IL-23 inhibitors for use in adults with moderate-to-severe plaque psoriasis.
Kristen M. Beck, Eric J. Yang, Sahil Sekhon, Tina Bhutani   +3 more
openaire   +1 more source

Serum IL-23 in asthmatic children.

Journal of biological regulators and homeostatic agents, 2012
Asthma is characterized by airway inflammation that is controlled by a complex cytokine network. The Th1/Th2 imbalance has been well documented in the pathogenesis of allergic asthma. Recently, Th17 cells and regulatory T (Treg) cells have been found to participate in the pathogenesis of allergic asthma.
Ciprandi G, Cuppari C, Salpietro A, Tosca M, Grasso L, RIGOLI, Luciana Concetta, La Rosa M, Marseglia GL, Miraglia Del Giudice M, SALPIETRO DAMIANO, Carmelo   +9 more
openaire   +3 more sources

The role of IL 23 in the treatment of psoriasis

Expert Review of Clinical Immunology, 2017
The IL-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis. Human IL-23 is primarily produced by antigen-presenting cells and induces and maintains differentiation of Th17 cells and Th22 cells, a primary cellular source of proinflammatory cytokines such as IL-17 and IL-22, which mediate the epidermal hyperplasia ...
openaire   +3 more sources

IL-23 in inflammatory bowel diseases and colon cancer.

Cytokine & growth factor reviews, 2019
Studies in recent years have identified a pivotal role of the cytokine IL-23 in the pathogenesis of inflammatory bowel diseases (IBD: Crohn´s disease, ulcerative colitis) and colitis-associated colon cancer. Genetic studies revealed that subgroups of IBD
M. Neurath
semanticscholar   +1 more source

IL-23 in Health and Disease

2013
The discovery of IL-23 and characterization of the biology governed by this cytokine has led to dramatic new insights within immunology. IL-23 is central to the pathogenesis of many immune-mediated inflammatory disorders and was shown to act via a novel IL-17-producing T helper subset, the Th17 cell.
Jonathan P. Sherlock, Luis A. Zuniga, Daniel J. Cua   +2 more
openaire   +1 more source

Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis

Rheumatology International, 2009
The objective of this study was to investigate the expression of IL-23 and IL-17 and the influence of IL-23 on IL-17 production in ankylosing spondylitis (AS) patients. IL-23 and IL-17 levels in the serum and supernatants of cultured peripheral blood mononuclear cells (PBMCs) were determined by ELISA.
Xinwei, Wang, Zhiming, Lin, Qiujing, Wei, Yingjuan, Jiang, Jieruo, Gu   +4 more
openaire   +2 more sources

The Involvement of IL-23 and the Th17 Pathway in Periodontitis

Journal of Dental Research, 2009
Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in periodontal lesions and control ...
H, Ohyama, N, Kato-Kogoe, A, Kuhara, F, Nishimura, K, Nakasho, K, Yamanegi, N, Yamada, M, Hata, J, Yamane, N, Terada   +9 more
openaire   +2 more sources

Emerging role of IL-23 in rheumatoid arthritis

Clinical Rheumatology, 2011
Dear Editor, Emerging evidence suggests that Th17 cells play a role in rheumatoid arthritis (RA) and is dependent on IL-23 for their survival and expansion [1]. Along this line, Singh et al. [2] reported that Th17 associated cytokines, particularly IL-17, IL-1β, IL-6, IL-21, IL-23, and TGF-β, in synovial fluid of reactive arthritis (ReA) and ...
Feng-Lai, Yuan, Xia, Li, Jun-Ming, Sun, Rui-Sheng, Xu   +3 more
openaire   +2 more sources