Results 251 to 260 of about 5,569,467 (288)

ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs. [PDF]

J Exp Clin Cancer Res
Talarico G, Lecchi M, Zanichelli A, Portararo P, Botti L, Cappelletti V, Costanza M, Piva A, Pratesi P, Bertolini F, Di Nicola M, Tripodo C, Cancila V, Pupa SM, Colombo MP, Chiodoni C, Verderio P, Sangaletti S.   +17 more
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IL-23 and the Tumor Microenvironment.

Advances in Experimental Medicine and Biology, 2021
The tumor microenvironment (TME), which assists in the development, progression, and metastasis of malignant cells, is instrumental in virtually every step of tumor development. While a healthy TME can protect against malignancy, in an unhealthy state, it can result in aberrant cellular behavior and augment tumor progression.
S. Subhadarshani, N. Yusuf, C. Elmets
semanticscholar   +3 more sources

Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis.

The Lancet, 2021
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated erythematous and scaly skin lesions accompanied by systemic manifestations.
K. Ghoreschi, A. Balato, C. Enerbäck, R. Sabat   +3 more
semanticscholar   +1 more source

Local IL-23 is required for proliferation and retention of skin-resident memory Th17 cells

Science immunology, 2022
The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear.
S. Whitley, Mushi Li, S. Kashem, T. Hirai, B. Igyártó, Kelley Knizner, Jonhan Ho, Laura Ferris, C. Weaver, D. Cua, M. McGeachy, D. Kaplan   +11 more
semanticscholar   +1 more source

IL‐23 in the Pathogenesis of Rheumatoid Arthritis

Scandinavian Journal of Immunology, 2010
AbstractInterleukin‐23 (IL‐23) is a heterodimeric cytokine belonging to the IL‐6/IL‐12 family that plays a key role in several of autoimmune and inflammatory disorders. This family contains the 34 type I cytokine receptor chains and 27 ligands, which share structural and functional similarities, but on the other hand they display distinct roles in ...
A, Paradowska-Gorycka, A, Grzybowska-Kowalczyk, E, Wojtecka-Lukasik, S, Maslinski   +3 more
openaire   +2 more sources

IL-23/Th17 Axis: A Potential Therapeutic Target of Psoriasis.

Current Drug Research Reviews, 2021
Psoriasis is an immune-mediated skin disease that leads to the initiation of abnormal production of inflammatory mediators and keratinocytes hyper-proliferation.
Amit Sharma, Deepak Kumar Upadhyay, G. Gupta, R. Narang, V. K. Rai   +4 more
semanticscholar   +1 more source

Targeting IL-23 in Crohn’s disease

Expert Review of Clinical Immunology, 2018
Interleukin (IL)-23, a cytokine produced by antigen presenting cells, targets both T cells and non-T cell types with the downstream effect of enhancing inflammatory pathways. Genome-wide association studies and data from human and mouse models of intestinal inflammation support the pathogenic role of IL-23 in Crohn's disease (CD), an immune-mediated ...
Silvia, Sedda, Gerolamo, Bevivino, Giovanni, Monteleone   +2 more
openaire   +2 more sources

Targeting IL-23 in human diseases

Expert Opinion on Therapeutic Targets, 2010
IL-23 is one of the most intriguing cytokine for its many immunological functions, which are the basis of its important role in host defense but also of its possible contribution to the pathogenesis of several diseases.The literature and patents about IL-23 pathway and their targeting in therapeutic potential applications. Findings published within the
D'ELIOS, MARIO MILCO, DEL PRETE, GIANFRANCO, AMEDEI, AMEDEO   +2 more
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IL-23 inhibition for the treatment of psoriatic arthritis

Expert Opinion on Biological Therapy, 2021
Psoriatic arthritis (PsA) is a complex, polygenic immune-mediated disease with varying clinical presentations involving the skin, nails, entheses, and axial/peripheral skeleton.Pathophysiology of PsA with special focus on IL-23/IL-17 axis. Novel classes of targeted therapies for PsA. Pharmacologic properties, efficacy and safety of guselkumab, the only
Raagav, Mohanakrishnan, Secia, Beier, Atul, Deodhar   +2 more
openaire   +2 more sources

Targeting the IL-23 Pathway in Inflammatory Bowel Disease.

Gastroenterology
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, maintains intestinal homeostasis but is also implicated in the pathogenesis of inflammatory bowel diseases (IBD). The IL-23 receptor (IL-23R) is a heterodimer composed of disulfide-linked
A. Bourgonje, R. Ungaro, S. Mehandru, J. Colombel   +3 more
semanticscholar   +1 more source