Results 121 to 130 of about 62,619,193 (270)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Age affects drug survival rates of interleukin (IL)-17 and IL-23 inhibitors in patients with plaque psoriasis: Results from a retrospective, multicentric, multi-country, cohort study

Background: Scarce data related to the drug survival of biologic agents in psoriasis patients aged >= 65 years is available. Objectives: To evaluate the drug survival of interleukin (IL)-23 or the IL-17 inhibitors approved for the treatment of ...
Torres, Tiago, Del Alcázar-Viladomiu, Elena, Carrascosa, José-Manuel, Gisondi, Paolo, Stratigos, Alexander J, Teixeira, Laetitia, Prignano, Francesca, Gkalpakiotis, Spyridon, Vender, Ron, Messina, Francesco, Di Brizzi, Eugenia Veronica, Lynde, Charles, Chiricozzi, Andrea, Piaserico, Stefano, Ricceri, Federica, Alessandri-Bonetti, Mario, Bruni, Manfredo, Romanelli, Marco, Conrad, Curdin, Dauden, Esteban, Mufti, Asfandyar, Leite, Luiz, Rompoti, Natalia, Valerio, Joana, Peris, Ketty, Nidegger, Alessia, Daponte, Athina-Ioanna, Lazaridou, Elizabeth, Vilarrasa, Eva, Balato, Anna, Llamas-Velasco, Mar, Nogueira, Miguel, Puig, Luis, Yeung, Jensen, Ferreira, Paulo, Bastos, Pedro Mendes, Coscarella, Giulia, Hugo, Jan   +37 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Clinical and scintigraphic improvement of mandibular involvement associated with chronic nonbacterial osteitis following an interleukin-23 inhibitor: a case-based literature review

Immunological Medicine
Chronic nonbacterial osteitis (CNO) occasionally presents with severe and refractory mandibular involvement, conventionally called as diffuse sclerosing osteomyelitis.
Koji Suzuki, Mitsuhiro Akiyama, Koichi Saito, Hiroshi Takei, Yuko Kaneko   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

IL-23 inhibitor guselkumab shows promise for PsA [PDF]

Nature Reviews Rheumatology, 2020
openaire   +2 more sources

Dysbiosis of the human skin mycobiome in patients receiving systemic IL-23 inhibitors

Allergology International
Systemic inhibition of pro-inflammatory cytokines affects the skin microbiome; however, the impact of systemic anti-inflammatory therapy on the skin fungal microbiome is poorly understood. To examine the effects of cytokine inhibition on the fungal community on human skin and oral mucosa, we analyzed the composition of the skin mycobiome before and ...
Yuta Koike, Sayaka Kuwatsuka, Daisuke Motooka, Hiroyuki Murota   +3 more
openaire   +3 more sources

Next-Generation Therapeutics for Perianal Fistulizing Crohn’s Disease: The Anticipated Impact of IL-23 Inhibitors

Hail Journal of Health Sciences
Background: Perianal fistulizing Crohn’s disease (PFCD) remains a formidable complication of Crohn’s disease (CD), affecting up to 30%–50% of patients and associated with significant morbidity.
Alfadl Abdulfattah
doaj   +1 more source

Major cardiovascular events under biologic psoriasis therapies: a 19-year real-world analysis of FAERS data

Frontiers in Immunology
ObjectiveOver the years when biologic psoriasis therapies (TNF inhibitors, IL-12/23 inhibitors, IL-23 inhibitors, and IL-17 inhibitors) have been used in psoriasis patients, reports of major cardiovascular events (MACEs) have emerged.
Lingqing Ding, Congqin Chen, Yongkuan Yang, Xiaoting Zhang   +3 more
doaj   +1 more source