Results 131 to 140 of about 7,958,059 (273)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Age affects drug survival rates of interleukin (IL)-17 and IL-23 inhibitors in patients with plaque psoriasis: Results from a retrospective, multicentric, multi-country, cohort study

Background: Scarce data related to the drug survival of biologic agents in psoriasis patients aged >= 65 years is available. Objectives: To evaluate the drug survival of interleukin (IL)-23 or the IL-17 inhibitors approved for the treatment of ...
Torres, Tiago, Del Alcázar-Viladomiu, Elena, Carrascosa, José-Manuel, Gisondi, Paolo, Stratigos, Alexander J, Teixeira, Laetitia, Prignano, Francesca, Gkalpakiotis, Spyridon, Vender, Ron, Messina, Francesco, Di Brizzi, Eugenia Veronica, Lynde, Charles, Chiricozzi, Andrea, Piaserico, Stefano, Ricceri, Federica, Alessandri-Bonetti, Mario, Bruni, Manfredo, Romanelli, Marco, Conrad, Curdin, Dauden, Esteban, Mufti, Asfandyar, Leite, Luiz, Rompoti, Natalia, Valerio, Joana, Peris, Ketty, Nidegger, Alessia, Daponte, Athina-Ioanna, Lazaridou, Elizabeth, Vilarrasa, Eva, Balato, Anna, Llamas-Velasco, Mar, Nogueira, Miguel, Puig, Luis, Yeung, Jensen, Ferreira, Paulo, Bastos, Pedro Mendes, Coscarella, Giulia, Hugo, Jan   +37 more
core   +2 more sources

Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review

Dermatology and Therapy
Introduction Dissecting cellulitis of the scalp (DCS) is a chronic, relapsing neutrophilic scarring alopecia within the follicular occlusion spectrum.
Kevin Díez-Madueño, Belén Argüello-Marcos, Diego Buendía-Castaño, María Ángeles Martín-Díaz, David Saceda-Corralo   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Biologic Sequence for the Treatment of Psoriatic Arthritis Following Nonresponse: A Narrative Review

Dermatology and Therapy
Psoriatic arthritis (PsA) is a complex, heterogeneous disease affecting multiple domains which necessitates a nuanced approach to treatment. While tumor necrosis factor (TNF) inhibitors have historically been the preferred first line therapy, increasing ...
Nicole D. Boswell, Alexa Ries, Kenneth B. Gordon, Shikha Singla   +3 more
doaj   +1 more source

IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response.

, 2020
Cytokines maintain intestinal health, but precise intercellular communication networks remain poorly understood. Macrophages are immune sentinels of the intestinal tissue and are critical for gut homeostasis.
Louise Chappell-Maor (2559871), Eyal David (669456), Eran Elinav (192785), Venizelos Papayannopoulos (193171), Masha Kolesnikov (8272896), Caterina Curato (768889), Steffen Jung (192792), Marianna Ioannou (5211254), Alon Harmelin (43332), Biana Bernshtein (6634181), Qian Wang (32718), Christoph A Thaiss (8272890), Mor Gross-Vered (8272893), Paresh Thakker (2433097)   +13 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

With guselkumab, does the dual mechanisms to inhibit IL-23, help in ulcerative colitis?

Introduction: Ulcerative colitis (UC) includes a dysregulated immune response. The conventional therapy includes immunosuppressants, and biologics targeting inflammatory mediators, but these are often inadequate, or subjects become unable to tolerate ...
Doggrell, Sheila A
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Efficacy and Safety of IL-12/23 and IL-23 Inhibitors for Crohn's Disease: Systematic Review and Meta-Analysis. [PDF]

Dig Dis Sci, 2023
Vuyyuru SK, Solitano V, Hogan M, MacDonald JK, Zayadi A, Parker CE, Sands BE, Panaccione R, Narula N, Feagan BG, Singh S, Jairath V, Ma C.   +12 more
europepmc   +1 more source