Results 151 to 160 of about 7,958,059 (273)

IL-23 Inhibitors in Psoriasis: What Have We Learnt so Far? [PDF]

J Inflamm Res
Megna M, D'Agostino M, Feo F, Ventura V, Tommasino N, Potestio L.   +5 more
europepmc   +1 more source

NAIL PSORIASIS AS A DIFFICULT-TO-TREAT AREA: COMPARATIVE EVIDENCE FOR IL-17 AND IL-23 INHIBITORS

Nail psoriasis is a frequent and clinically relevant manifestation of psoriasis, affecting a substantial proportion of patients with plaque psoriasis and psoriatic arthritis.
Napiórkowska, Katarzyna, Popielarczyk, Melania, Płaza, Dominik, Góralska, Julia, Kujach, Aleksandra   +4 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Drug survival of IL-12/23, IL-17 and IL-23 inhibitors for moderate-to-severe plaque psoriasis: a retrospective multicenter real-world experience on 5932 treatment courses - IL PSO (Italian landscape psoriasis). [PDF]

Front Immunol, 2023
Gargiulo L, Ibba L, Malagoli P, Balato A, Bardazzi F, Burlando M, Carrera CG, Damiani G, Dapavo P, Dini V, Gaiani FM, Girolomoni G, Guarneri C, Lasagni C, Loconsole F, Marzano AV, Megna M, Mercuri SR, Travaglini M, Costanzo A, Narcisi A.   +20 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

High-Dose, Extended Half-Life IL-23 Inhibitors: the Next Big Step in Psoriasis Care? [PDF]

Dermatol Ther (Heidelb)
Torres T, Blauvelt A.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

New Tuberculosis Infection and Reactivation of Tuberculosis in Patients with Psoriasis or Psoriatic Arthritis Receiving IL-23 Inhibitors: A Systematic Literature Review. [PDF]

Dermatol Ther (Heidelb)
Wang G, Youn SW, Chang CL, Saeki H.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Drug retention of TNF versus IL-23 inhibitors in psoriatic arthritis: a multicenter real-life cohort study. [PDF]

Ther Adv Musculoskelet Dis
Parisi S, Becciolini A, D'Onofrio B, Lo Gullo A, Addimanda O, Magnani M, Reta M, Andracco R, Mansueto N, Del Medico P, Caccavale R, Paroli M, Larosa M, Bianchi G, Camellino D, Raffeiner B, Nucera V, Ianniello A, Giampietro C, Ometto F, Priora M, Molica Colella AB, Bravi E, Platè I, Arrigoni E, Ravagnani V, Bezzi A, Mascella F, Focherini MC, Fiorenza A, Rovera G, Vitetta R, Scolieri P, Bruzzese V, Volpe A, Bixio R, Marchetta A, Lumetti F, Farina A, Bernardi S, Girelli F, Visalli E, Amato G, De Lucia F, Dal Bosco Y, Foti R, Foti R, Serale F, Cipollone F, Di Penta M, Sabatini E, Celletti E, Franchina V, Colella FM, Ferrero G, Sandri G, Giuggioli D, Ditto MC, Fusaro E, Adorni G, Di Donato E, Santilli D, Lucchini G, Ariani A.   +63 more
europepmc   +1 more source