The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis [PDF]
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R)
Daphne Peerlings +2 more
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Biological significance of soluble IL-2 receptor [PDF]
Mediators of Inflammation, 1993 A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-
Calogero Caruso +4 more
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The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors [PDF]
Clinical and Developmental Immunology, 1998 On the basis of both the interleukin‐2‐receptor (IL‐2R) α‐chain expression on 16‐day‐old fetal rat thymocytes and the occurrence of interleukin‐2 (IL‐2) mRNA‐containing cells early during rat thymus ontogeny, we have investigated the possible role of IL‐2/IL‐2R complex in rat T‐cell maturation.
Alberto Varas +5 more
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Impact of serum levels of IL-18 and soluble IL-2 receptor on the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP regimen [PDF]
Future Science OA, 2019 Aim & methods: To assess the impact of pretreatment serum levels of IL-18 and soluble IL-2 receptor (sIL-2R) on the clinical outcome of patients with diffuse large B-cell lymphoma treated with an R-CHOP protocol. Total 73 patients were included. Results:
Hussein M Khaled +4 more
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Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder (Paralichthys olivaceus) [PDF]
Frontiers in Immunology, 2020 Interleukin-2 (IL-2) is an important immunomodulatory cytokine that primarily promotes the activation, proliferation, and differentiation of CD4+ T helper subsets and CD4+ T regulatory cells.
Xiujuan Zhou +8 more
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Structure-function relationships for the IL 2-receptor system. I. Localization of a receptor binding site on IL 2. [PDF]
The Journal of Immunology, 1986 Abstract Interleukin 2 (IL 2) modulates the growth and differentiation of a variety of lymphocyte subclasses through its interaction with a specific cell surface receptor. Although both IL 2 and its receptor have been characterized extensively, the location of interaction sites on the two molecules is unknown. Synthetic peptides based on
Li-Mei Kuo, R J Robb
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Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling. [PDF]
Mol Ther, 2023 Luetkens T.
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Soluble interleukin-2 receptor in pediatric patients investigated for hemophagocytic lymphohistiocytosis: A single-center, 10-year-long experience [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2023 Introduction/Objective Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition characterized by fever, splenomegaly, and cytopenias.
Janković Srđa +5 more
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Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation
Frontiers in Immunology, 2022 Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases.
Dihia Meghnem +18 more
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Abstracts from the 1997 Eastern Student Research Forum
McGill Journal of Medicine, 2020 N/A.
Eastern Student Research Forum
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