Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance. [PDF]
J Clin Invest, 2021 Adoptive transfer of Tregs has been shown to improve alloengraftment in animal models. However, it is technically challenging to expand Tregs ex vivo for the purpose of infusing large numbers of cells in the clinic.
Toshihito Hirai +16 more
semanticscholar +2 more sources
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist [PDF]
Nat Commun, 2020 Interleukin-2 (IL-2) is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities.
Giulia Parisi +20 more
semanticscholar +2 more sources
Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues. [PDF]
PLoS ONE, 2014 Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The
Lucile E Wrenshall +7 more
doaj +5 more sources
Soluble interleukin-2 receptor in pediatric patients investigated for hemophagocytic lymphohistiocytosis: A single-center, 10-year-long experience [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2023 Introduction/Objective Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition characterized by fever, splenomegaly, and cytopenias.
Janković Srđa +5 more
doaj +1 more source
Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation
Frontiers in Immunology, 2022 Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases.
Dihia Meghnem +18 more
doaj +1 more source
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Molecular Cancer, 2023 Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted ...
Shan Muhammad +4 more
doaj +1 more source
Abstracts from the 1997 Eastern Student Research Forum
McGill Journal of Medicine, 2020 N/A.
Eastern Student Research Forum
doaj +1 more source
Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
doaj +1 more source
P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. [PDF]
PLoS ONE, 2015 As one member of G protein-coupled P2Y receptors, P2Y2 receptor can be equally activated by extracellular ATP and UTP. Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and ...
Wei-Hua Li +4 more
doaj +1 more source
Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. [PDF]
PLoS ONE, 2012 The intestinal microflora is critical for normal development, with aberrant colonization increasing the risk for necrotizing enterocolitis (NEC). In contrast, probiotic bacteria have been shown to decrease its incidence.
Julie Mirpuri +7 more
doaj +1 more source