The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis [PDF]
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R)
Daphne Peerlings +2 more
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The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells [PDF]
iScience, 2020 Summary: IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 ...
Adam T. Waickman +8 more
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IL-2 Receptor Expression in Renal Cell Carcinoma Cells: IL-2 Influences Cell Survival and Induces Cell Death [PDF]
Current Issues in Molecular BiologyRenal cell carcinoma (RCC) is the most common form of kidney cancer in adults. Immunotherapy, such as the application of interleukin-2 (IL-2), is a crucial treatment. It is known that IL-2 is involved in the upregulation of the anti-tumor immune response;
Sophie Grigolo +2 more
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Impact of serum levels of IL-18 and soluble IL-2 receptor on the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP regimen [PDF]
Future Science OA, 2019 Aim & methods: To assess the impact of pretreatment serum levels of IL-18 and soluble IL-2 receptor (sIL-2R) on the clinical outcome of patients with diffuse large B-cell lymphoma treated with an R-CHOP protocol. Total 73 patients were included. Results:
Hussein M Khaled +4 more
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IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor. [PDF]
Am J Transplant, 2022 Hirai T +9 more
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IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19 [PDF]
Frontiers in ImmunologyCD25 (IL-2 receptor alpha chain) is a key component of the high-affinity receptor for the IL-2 cytokine and regulates the proliferation, survival, and differentiation of immune cells.
Sruthi Vijaya Retnakumar +4 more
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Soluble interleukin-2 receptor in pediatric patients investigated for hemophagocytic lymphohistiocytosis: A single-center, 10-year-long experience [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2023 Introduction/Objective Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition characterized by fever, splenomegaly, and cytopenias.
Janković Srđa +5 more
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Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation
Frontiers in Immunology, 2022 Cytokines are crucial molecules for maintaining the proper functioning of the immune system. Nevertheless, a dysregulation of cytokine expression could be involved in the pathogenesis of autoimmune diseases.
Dihia Meghnem +18 more
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Abstracts from the 1997 Eastern Student Research Forum
McGill Journal of Medicine, 2020 N/A.
Eastern Student Research Forum
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Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Molecular Cancer, 2023 Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted ...
Shan Muhammad +4 more
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