Cellular Physiology and Biochemistry, 2016 Background/Aims: The bradykinin B2 receptor (BDKRB2) +9/-9 gene polymorphisms have been shown to be associated with the susceptibility and severity of osteoarthritis (OA); however, the underlying mechanisms are unclear. In this study, we investigated the
Shuo Chen +6 more
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A great disturbance in the force: IL-2 receptor defects disrupt immune homeostasis. [PDF]
Curr Opin Pediatr, 2022 Hernandez JD, Hsieh EWY.
europepmc +1 more source
CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. [PDF]
, 1992 Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal ...
Fraser, JD, Newton, ME, Weiss, A
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IL-2 Receptor-Targeted Cytolytic IL-2/Fc Fusion Protein Treatment Blocks Diabetogenic Autoimmunity in Nonobese Diabetic Mice [PDF]
, 1999 Xin Xiao Zheng +8 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells. [PDF]
Mol Ther, 2023 Cook PJ +13 more
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, 2012 Frank Neuschäfer‐Rube +4 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Induction in Pancreas Transplantation: T-cell Depletion Versus IL-2 Receptor Blockade. [PDF]
Transplant Direct, 2022 Aziz F +4 more
europepmc +1 more source