Results 121 to 130 of about 2,340,150 (306)

TheBDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies

Cellular Physiology and Biochemistry, 2016
Background/Aims: The bradykinin B2 receptor (BDKRB2) +9/-9 gene polymorphisms have been shown to be associated with the susceptibility and severity of osteoarthritis (OA); however, the underlying mechanisms are unclear. In this study, we investigated the
Shuo Chen, Lei Zhang, Ruonan Xu, Yunfan Ti, Yunlong Zhao, Liwu Zhou, Jianning Zhao   +6 more
doaj   +1 more source

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers [PDF]

, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Andrews, Bazan, Bazan, Bendall, Borden, Constantinescu, Delgoffe, Donohue, Fujiwara, Gil, Grant, Greenwell-Wild, Heller, Hoshino, Huising, Ihle, Jahn, Juntilla, Kasahara, Kawahara, Krutzik, Laporte, Lemmon, Levin, Levin, Levy, Marijanovic, Mitra, Moraga, Moraga, Moraga, Murray, Ng, O'Shea, Ohashi, Pattyn, Rafei, Saeed, Schaeffer, Sharif, Songyang, Spangler, Stroud, Thomas, Ullrich, Umemiya-Okada, van Boxel-Dezaire, Vercelli, Vignais, Wang, Wang, Wells, Wenzel, Zhu   +53 more
core   +2 more sources

A rat monoclonal antibody that binds specifically to mouse T lymphoblasts and inhibits IL 2 receptor functions: a putative anti-IL 2 receptor antibody.

Journal of Immunology, 1984
To obtain an anti-interleukin 2 (IL 2) receptor antibody, we immunized rats with phorbol myristate acetate-pulsed mouse T lymphoblasts. The spleen cells of the rats were fused with rat myeloma cells. Several stable clones of hybridoma cells were obtained
H. Osawa, T. Diamantstein
semanticscholar   +1 more source

Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for IL-15Rα [PDF]

, 2013
Interleukins 2 and 15 (IL-2 and IL-15) are highly differentiated but related cytokines with overlapping, yet also distinct functions, and established benefits for medical drug use.
Dijkstra,JM, Fischer,U, Friedrich,M, Hashimoto,K, Karger,A, Lefèvre,C, Lenk,M, Matsui,T, Soto-Lampe,V, Takizawa,F   +9 more
core   +1 more source

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

Journal of Neuroinflammation, 2012
Background Blockade of angiotensin II type 1 (AT1) receptors ameliorates brain inflammation, and reduces excessive brain interleukin-1 beta (IL-1β) production and release from cortical microglia.
Pang Tao, Wang Juan, Benicky Julius, Sánchez-Lemus Enrique, Saavedra Juan M   +4 more
doaj   +1 more source

A Low-Toxicity IL-2–Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity

Clinical Cancer Research, 2011
Purpose: The goal of the study was to engineer a form of interleukin 2 (IL-2) that, when delivered as a tumor-specific antibody fusion protein, retains the ability to stimulate an antitumor immune response via interaction with the high-affinity IL-2 ...
S. Gillies, Y. Lan, T. Hettmann, B. Brunkhorst, Yaping Sun, S. O. Mueller, K. Lo   +6 more
semanticscholar   +1 more source

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells. [PDF]

Mol Ther, 2023
Cook PJ, Yang SJ, Uenishi GI, Grimm A, West SE, Wang LJ, Jacobs C, Repele A, Drow T, Boukhris A, Dahl NP, Sommer K, Scharenberg AM, Rawlings DJ.   +13 more
europepmc   +1 more source

Modeling of anti-tumor immune response: immunocorrective effect of weak centimeter electromagnetic waves [PDF]

arXiv, 2005
We formulate the dynamical model for the anti-tumor immune response based on intercellular cytokine-mediated interactions with the interleukin-2 (IL-2) taken into account. The analysis shows that the expression level of tumor antigens on antigen presenting cells has a distinct influence on the tumor dynamics.
arxiv  

Angiotensin-(1–7) attenuates SARS-CoV2 spike protein-induced interleukin-6 and interleukin-8 production in alveolar epithelial cells through activation of Mas receptor

Journal of Microbiology, Immunology and Infection, 2023
Background: SARS-CoV-2 spike proteins (SP) can bind to the human angiotensin-converting enzyme 2 (ACE2) in human pulmonary alveolar epithelial cells (HPAEpiC) and trigger an inflammatory process.
Yi-Luen Shen, Yi-An Hsieh, Po-Wei Hu, Po-Chun Lo, Yi-Han Hsiao, Hsin-Kuo Ko, Fang-Chi Lin, Chien-Wen Huang, Kang-Cheng Su, Diahn-Warng Perng   +9 more
doaj  

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.

Blood, 1995
The interleukin-2 (IL-2) receptor gamma-chain is a common component of several members of the cytokine receptor superfamily including those for IL-2, IL-4, IL-7, IL-9, IL-15, and possibly IL-13, and has recently been renamed the common gamma-chain (gamma
DJ Matthews, P. Clark, J. Herbert, Gareth Morgan, Richard J. Armitage, Christine Kinnon, A. Minty, KH Grabstein, Daniel Caput, Pascual Ferrara   +9 more
semanticscholar   +1 more source