Results 201 to 210 of about 816,685 (307)

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

⁸⁹Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding. [PDF]

Oncotarget, 2018
van Brummelen EMJ, Huisman MC, de Wit-van der Veen LJ, Nayak TK, Stokkel MPM, Mulder ER, Hoekstra OS, Vugts DJ, Van Dongen GAMS, Verheul HM, Evers S, Tessier JJL, Saro J, Schellens JHM, Menke-van der Houven van Oordt CW.   +14 more
europepmc   +1 more source

IMMUNOGENIC EPITOPES OF THE p55 CHAIN OF THE IL-2 RECEPTOR RELATIONSHIPS TO HIGH-AFFINITY IL-2 BINDING AND MODULATION OF THE P55 CHAIN

, 1990
Johnson T. Wong, Eric M. Schott, ELIZABETH M. SABGA, G. Kielpinski, Robert B. Colvin   +4 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. [PDF]

Cancer Immunol Immunother, 2017
Neitzke DJ, Bowers JS, Andrijauskaite K, O'Connell NS, Garrett-Mayer E, Wrangle J, Li Z, Paulos CM, Cole DJ, Rubinstein MP.   +9 more
europepmc   +1 more source

Peripheral blood hairy cell leukemia cells express only low affinity IL-2 receptors

, 1994
Kyran Bulger, John R. Murphy, Anthony J. Janckila, Jean Nichols, Ronald P. McCaffrey   +4 more
openalex   +1 more source

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway [PDF]

, 1998
Tsuyoshi Miyazaki, Akinori Takaoka, Lourdes M. Nogueira, Ivan Đikić, Hodaka Fujii, Shuichi Tsujino, Yoshio Mitani, M Maeda, Joseph Schlessinger, Tadatsugu Taniguchi   +9 more
openalex   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

PHA induces IL-2 receptors on B-CLL cells and is a potential biological response modifier for the LIL-2-diphtheria toxin, DAB486IL-2

, 1994
Kyran Bulger, Florecita R. Padua, R. Joel Duff, Germán Pihán, Jean Nichols, John R. Murphy, Ronald P. McCaffrey   +6 more
openalex   +1 more source

Mechanisms of Trypanosoma cruzi-induced down-regulation of lymphocyte function. Inhibition of transcription and expression of IL-2 receptor gamma (p64IL-2R) and beta (p70IL-2R) chain molecules in activated normal human lymphocytes. [PDF]

, 1996
Sarmila Majumder, F Kierszenbaum
openalex   +1 more source