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The IL-2 IL-2 receptor system: A current overview
Cell, 1993Tadatsugu Taniguchi and Yasuhiro Mlnami Institute for Molecular and Cellular Biology Osaka University Yamadaoka 1-3, Suita-shi Osaka 565 Japan The discovery and molecular characterization of interleu- kin-2 (IL-2) has had a considerable impact on basic and clinical immunology(Morgan et al., 1976; Taniguchi et al., 1963; Rosenberg et al., 1965).
T. Taniguchi, Y. Minami
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Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.
Cytokine & Growth Factor Reviews, 2006 Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low ...
Hyoung-Pyo Kim, J. Imbert, W. Leonard
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Immunotherapy through the IL-2 receptor
Immunologic Research, 1992The IL-2 receptor system is a suitable target for immunotherapy in conditions in which activated (T) cells play a pivotal role, such as transplantation reactions and auto-immune diseases. Antibodies directed at the IL-2R can be used as such or modified by conjugation to toxins or through chelators to radiolabels.
H. A. M. Verheul, E. S. Bos, M. Verveld
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17-β-ESTRADIOL SUPPRESSES IL-2 AND IL-2 RECEPTOR
Cytokine, 2001Interleukin-2 (IL-2) plays an important role in adaptive immune responses. These responses differ between females and males and may be due to the sex steroid estrogen. In this investigation we show that estrogen suppresses IL-2 production from activated peripheral blood T cells and CD4+ T cell lines at the transcriptional level.
Robert W. McMurray +3 more
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Life Sciences, 2003
The existence and functions of muscarinic acetylcholine (mACh) receptors in human T lymphocytes were investigated. RT-PCR analysis demonstrated the presence of M(1) and M(2) subtypes of mACh receptors in human T lymphocytes. Pretreatment with oxotremorine-M (Oxo-M) caused the increase in phytohemagglutinin-induced IL-2 production.
Yasunobu Okuma +3 more
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The existence and functions of muscarinic acetylcholine (mACh) receptors in human T lymphocytes were investigated. RT-PCR analysis demonstrated the presence of M(1) and M(2) subtypes of mACh receptors in human T lymphocytes. Pretreatment with oxotremorine-M (Oxo-M) caused the increase in phytohemagglutinin-induced IL-2 production.
Yasunobu Okuma +3 more
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Structure and Regulation of the Human IL-2 Receptor [PDF]
, 1989 The growth of human T lymphocytes can be divided into two discrete stages resembling competence and progression. In the first stage, the binding of antigen or mitogen to specific T cell receptors triggers the transduction of intracellular signals leading to cellular activation1,2. In turn, these activation signals induce the de novo expression of genes
Miriam Siekevitz +5 more
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The IL-2 receptor complex: its structure, function, and target genes.
Annual Review of Immunology, 1993Proliferation of T lymphocytes is triggered by the interaction of IL-2 with its specific receptor following T lymphocyte activation. The receptor for IL-2 consists of at least three distinct subunits, the alpha chain (IL-2R alpha), the beta chain (IL-2R ...
Yasuhiro Minami +3 more
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The Journal of Immunology, 1993
Abstract Binding of IL-2 to the high affinity IL-2R results in the formation of a stable complex consisting of IL-2 and at least three distinct, noncovalently associated receptor subunits: IL-2R alpha (p55), IL-2R beta (p70-75), and IL-2R gamma (p64). Ligand binding also stimulates the rapid endocytosis of this receptor complex.
W A, Kuziel +3 more
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Abstract Binding of IL-2 to the high affinity IL-2R results in the formation of a stable complex consisting of IL-2 and at least three distinct, noncovalently associated receptor subunits: IL-2R alpha (p55), IL-2R beta (p70-75), and IL-2R gamma (p64). Ligand binding also stimulates the rapid endocytosis of this receptor complex.
W A, Kuziel +3 more
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Signaling from the IL-2 receptor to the nucleus
Cytokine & Growth Factor Reviews, 1997Interleukin-2 has pleiotropic actions on the immune system and plays a vital role in the modulation of immune responses. Our current understanding of IL-2 signaling has resulted from in vitro studies that have identified the signaling pathways activated by IL-2, including the Jak-STAT pathways, and from in vivo studies that have analyzed mice in which ...
Jian-Xin Lin, Warren J. Leonard
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Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
Science, 1994The interleukin-2 receptor (IL-2R) consists of three subunits: the IL-2R alpha, IL-2R beta, and IL-2R gamma chains, the last of which is also used in the receptors for IL-4, IL-7, and IL-9.
Tadaaki Miyazaki +10 more
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