Results 261 to 270 of about 2,340,150 (306)
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Immunopharmacology, 1993
In the present study we have examined the effect of a Ca2+ channel blocker (verapamil) on the binding of IL-2 to its biologically active receptor (IL-2R), as well as on the release of its soluble form (sIL-2R) by peripheral blood mononuclear cells (PBMC) stimulated by a variety of stimuli. In the same culture systems, cyclosporine A (CsA) was also used
Jana Raskova +3 more
openaire +3 more sources
In the present study we have examined the effect of a Ca2+ channel blocker (verapamil) on the binding of IL-2 to its biologically active receptor (IL-2R), as well as on the release of its soluble form (sIL-2R) by peripheral blood mononuclear cells (PBMC) stimulated by a variety of stimuli. In the same culture systems, cyclosporine A (CsA) was also used
Jana Raskova +3 more
openaire +3 more sources
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
Science, 1994When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy.
V. Boussiotis +8 more
semanticscholar +1 more source
Transplantation, 1989
Patients were entered into a randomized trial of prophylaxis for renal allograft rejection by the administration of an anti-human IL-2 receptor antibody, anti-Tac, during the first ten days posttransplant. Interleukin-2 receptor (IL-2 R) expression was measured using two anti-IL-2 R monoclonal antibodies (moAbs), anti-Tac and 1HT4-4H3.
Nicholas L. Tilney +9 more
openaire +3 more sources
Patients were entered into a randomized trial of prophylaxis for renal allograft rejection by the administration of an anti-human IL-2 receptor antibody, anti-Tac, during the first ten days posttransplant. Interleukin-2 receptor (IL-2 R) expression was measured using two anti-IL-2 R monoclonal antibodies (moAbs), anti-Tac and 1HT4-4H3.
Nicholas L. Tilney +9 more
openaire +3 more sources
Science, 1988
Jurkat T cell lines constitutively expressing Tax, the 40-kilodalton transactivator protein of human T lymphotropic virus type I (HTLV-I), were used to investigate the mechanism by which this viral product deregulates the expression of the interleukin-2 ...
D. Ballard +5 more
semanticscholar +1 more source
Jurkat T cell lines constitutively expressing Tax, the 40-kilodalton transactivator protein of human T lymphotropic virus type I (HTLV-I), were used to investigate the mechanism by which this viral product deregulates the expression of the interleukin-2 ...
D. Ballard +5 more
semanticscholar +1 more source
The IL-2/IL-2 receptor system: a target for rational immune intervention
Trends in Pharmacological Sciences, 1993The expression of interleukin 2 (IL-2), induction of its multisubunit receptor and subsequent interplay of this ligand with its receptor are pivotal events in T-cell activation. Our present understanding of the normal IL-2/IL-2R system and of disorders in this network in disease opens the possibility for more specific immune intervention.
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The Journal of Immunology, 1995
Abstract The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma), and heterotrimeric (alpha beta
M A, Goldsmith, M C, Amaral, W C, Greene
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Abstract The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma), and heterotrimeric (alpha beta
M A, Goldsmith, M C, Amaral, W C, Greene
openaire +2 more sources
IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development
, 1994The analysis of the expression of the alpha chain of the IL-2 receptor (CD25, TAC) on the surface of B lineage cells in mouse bone marrow reveals that it is a useful marker to distinguish pre-B-I from pre-B-II cells. CD25 is not expressed on CD45R(B220)+
A. Rolink +4 more
semanticscholar +1 more source
Highlight: IL-2 receptor signaling
Science Signaling, 2017Two papers reveal the consequences of altered interleukin-2 receptor signaling in T lymphocytes.
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Interleukin-2 (IL-2) and its receptor
Medical Oncology and Tumor Pharmacotherapy, 1986The interleukin-2 (IL-2) receptor system which is responsible for T-cell cycle progression is a unique hormone-receptor system in that both the ligand and the receptor need to be induced. In the present article I will review the biological and molecular characteristics of IL-2 and its receptor, as well as the differential triggering and growth ...
openaire +3 more sources
Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.
Science, 1994The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect.
M. Kondo +6 more
semanticscholar +1 more source