Results 311 to 320 of about 1,313,952 (350)
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Immunopharmacology, 1993
In the present study we have examined the effect of a Ca2+ channel blocker (verapamil) on the binding of IL-2 to its biologically active receptor (IL-2R), as well as on the release of its soluble form (sIL-2R) by peripheral blood mononuclear cells (PBMC) stimulated by a variety of stimuli. In the same culture systems, cyclosporine A (CsA) was also used
Jana Raskova +3 more
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In the present study we have examined the effect of a Ca2+ channel blocker (verapamil) on the binding of IL-2 to its biologically active receptor (IL-2R), as well as on the release of its soluble form (sIL-2R) by peripheral blood mononuclear cells (PBMC) stimulated by a variety of stimuli. In the same culture systems, cyclosporine A (CsA) was also used
Jana Raskova +3 more
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Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4
Science, 1993The γ chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the γ chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line ...
Naoto Ishii +6 more
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Transplantation, 1989
Patients were entered into a randomized trial of prophylaxis for renal allograft rejection by the administration of an anti-human IL-2 receptor antibody, anti-Tac, during the first ten days posttransplant. Interleukin-2 receptor (IL-2 R) expression was measured using two anti-IL-2 R monoclonal antibodies (moAbs), anti-Tac and 1HT4-4H3.
Nicholas L. Tilney +9 more
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Patients were entered into a randomized trial of prophylaxis for renal allograft rejection by the administration of an anti-human IL-2 receptor antibody, anti-Tac, during the first ten days posttransplant. Interleukin-2 receptor (IL-2 R) expression was measured using two anti-IL-2 R monoclonal antibodies (moAbs), anti-Tac and 1HT4-4H3.
Nicholas L. Tilney +9 more
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The IL-2/IL-2 receptor system: a target for rational immune intervention
Trends in Pharmacological Sciences, 1993The expression of interleukin 2 (IL-2), induction of its multisubunit receptor and subsequent interplay of this ligand with its receptor are pivotal events in T-cell activation. Our present understanding of the normal IL-2/IL-2R system and of disorders in this network in disease opens the possibility for more specific immune intervention.
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Highlight: IL-2 receptor signaling
Science Signaling, 2017Two papers reveal the consequences of altered interleukin-2 receptor signaling in T lymphocytes.
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Interleukin-2 (IL-2) and its receptor
Medical Oncology and Tumor Pharmacotherapy, 1986The interleukin-2 (IL-2) receptor system which is responsible for T-cell cycle progression is a unique hormone-receptor system in that both the ligand and the receptor need to be induced. In the present article I will review the biological and molecular characteristics of IL-2 and its receptor, as well as the differential triggering and growth ...
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The Journal of Immunology, 1995
Abstract The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma), and heterotrimeric (alpha beta
M A, Goldsmith, M C, Amaral, W C, Greene
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Abstract The biologic actions of IL-2 are mediated by the IL-2R, a multisubunit receptor complex displayed on the surface of lymphocytes and select other hematopoietic lineages. The IL-2R exhibits multiple affinities for IL-2 that result from the monomeric (alpha), heterodimeric (alpha beta and beta gamma), and heterotrimeric (alpha beta
M A, Goldsmith, M C, Amaral, W C, Greene
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European Journal of Immunology, 1995
AbstractMouse fibroblasts do not ordinarily express components for the interleukin‐2 receptor (IL‐2Rα, β, and γ). An analysis of these cells by reverse transcription followed by polymerase chain reaction, however, indicates the presence of transcripts specific for the IL‐2R β and γ genes. Transfection of the cDNA for the α chain of the human IL‐2R into
Bruno Azzarone +8 more
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AbstractMouse fibroblasts do not ordinarily express components for the interleukin‐2 receptor (IL‐2Rα, β, and γ). An analysis of these cells by reverse transcription followed by polymerase chain reaction, however, indicates the presence of transcripts specific for the IL‐2R β and γ genes. Transfection of the cDNA for the α chain of the human IL‐2R into
Bruno Azzarone +8 more
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Differential Effects of IL-2 and IL-15 on Expression of IL-2 Receptor α
Biochemical and Biophysical Research Communications, 2001IL-2 and IL-15 have overlapping functions since they share the IL-2Rbetagamma receptor complex. However, each cytokine has a private alpha receptor namely IL-2Ralpha for IL-2 and IL-15Ralpha for IL-15. As a consequence the effects of the two cytokines may differ.
Adelkrim Alileche +2 more
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Transcription and translation dependent induction of interleukin 2 (IL-2) and IL-2 receptors
Immunology Letters, 1984Our previous findings on the expression of Interleukin 2 (IL-2) receptors have shown that under the influence of certain drugs, it was possible to dissociate IL-2 production from the appearance of IL-2 receptors on human peripheral blood lymphocytes (PBL).
A.L. de Weck +3 more
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