Results 91 to 100 of about 5,139,608 (255)

IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms

, 2018
Protection against microbial infection by the induction of inflammation is a key function of the IL-1 superfamily, including both classical IL-1 and the new IL-36 cytokine families.
Coleman, Bianca M., Diksha Sihra, Sarah L. Gaffen, Naglik, Julian R.; id_orcid, Stacey, M, Richardson, JP, Gaffen, SL, Gaffen, Sarah L., McGeachy, Mandy J., Sihra, D, Martin Stacey, Richardson, Jonathan P.; id_orcid, Zafar, H, Hepworth, OW, Olivia W. Hepworth, Verma, Akash H., Aggor, FEY, Ponde, NO, Felix E. Y. Aggor, Julian R. Naglik, Zafar, Hanna, Stacey, Martin, Jemima Ho, Hepworth, Olivia W., Hube, B, Ho, J, Aggor, Felix E. Y., Joseph S. Ainscough, Coleman, BM, Akash H. Verma, Jonathan P. Richardson, Moyes, DL, Hanna Zafar, Moyes, Dave; id_orcid, Ainscough, Joseph S., Bianca M. Coleman, David L. Moyes, Verma, AH, Ponde, Nicole O., Bernhard Hube, McGeachy, MJ, Nicole O. Ponde, Hube, Bernhard, Sihra, Diksha, Naglik, JR, Mandy J. McGeachy, Ainscough, JS, Ho, Jemima   +47 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Il modello di business

, 2011
Il capitolo presenta i risultati di un questionario rivolto agli intermediari bancari italiani che operano nel comparto del microcredito finalizzato ad indagare lo stato dell'arte di questo business (margini prodotti, modalità di valutazione del rischio,
PORRETTA, Pasqualina
core  

Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis [PDF]

, 2019
Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous drug reaction. Although an involvement of drug-specific T cells has been reported, the physiopathology of AGEP and mechanism of neutrophilic skin inflammation remain ...
Mellett, Mark, Laurence Feldmeyer, Barbara Meier-Schiesser, Chung, Wen-Hung, Yawalkar, Nikhil, Daniel Yerly, Yerly, Daniel, Alexander Navarini, Satoh, Takashi K, Wen-Hung Chung, Mellett, Mark; https://orcid.org/, Abe, Riichiro, French, Lars E, Meier-Schiesser, Barbara, Nikhil Yawalkar, French, Lars E., Mark Mellett, Riichiro Abe, Emmanuel Contassot, Contassot, Emmanuel, Satoh, Takashi K., Jankovic, Dragana, Dragana Jankovic, Feldmeyer, Laurence, Navarini, Alexander, Lars E. French, Takashi K. Satoh   +26 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

IL rapporto tra art. 36 Cost. e i CCNL. La prescrizione della retribuzione

, 2017
analisi degli orientamenti dottrinali e giurisprudenziali sull'art.
lorenzo zoppoli
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Therapeutic Potential of IL-1 Antagonism in Hidradenitis Suppurativa

Biomolecules
The immunopathogenesis of HS is partially understood and exhibits features of an autoinflammatory disease; it is associated with the potential involvement of B cells and the contribution of Th1 or Th17 cell subsets.
Laura Calabrese, Dalma Malvaso, Giulia Coscarella, Flaminia Antonelli, Alessandra D’Amore, Niccolò Gori, Pietro Rubegni, Ketty Peris, Andrea Chiricozzi   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source