Results 11 to 20 of about 55,844,280 (246)

IL-39 increases ROS production and promotes the phosphorylation of p38 MAPK in the apoptotic cardiomyocytes [PDF]

Folia Histochemica et Cytobiologica, 2021
INTRODUCTION: The cytokine interleukin (IL)-39 is a novel member of the IL-12 family. Our previous study found that the serum level of IL-39 significantly increased in patients with acute myocardial infarction. However, the role of IL-39 in cardiomyocyte
Wei Xiong, Hua Chen, Jiequan Lu, Jie Ren, Chen Nie, Ruijuan Liang, Feng Liu, Baofeng Huang, Yu Luo   +8 more
doaj   +5 more sources

Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis. [PDF]

Clin Oral Investig, 2022
AbstractObjectivesIL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin.Materials and methodsSixty-six adult patients were included in the study. The study design
Sari A, Dogan S, Nibali L, Koseoglu S.
europepmc   +5 more sources

The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man. [PDF]

Inflamm Res, 2019
The heterodimeric IL-12 family member cytokines including, IL-12, IL-23, IL-27, and IL-35 and have multiple roles in regulating innate and adaptive immunity with crucial functions in inflammatory disorders such as psoriasis. Chain pairing promiscuity is a feature of the IL-12 family.
Bridgewood C, Alase A, Watad A, Wittmann M, Cuthbert R, McGonagle D.   +5 more
europepmc   +8 more sources

IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling. [PDF]

Sci Rep, 2017
AbstractIL-35 and IL-39 are recently discovered shared members of the IL-6- and IL-12–type cytokine family with immune-suppressive capacity. IL-35 has been reported to induce the formation of four different receptor complexes: gp130:IL-12β2, gp130:gp130, IL-12β2:IL-12β2, and IL-12β2:WSX-1. IL-39 was proposed to form a gp130:IL-23R receptor complex.
Floss DM, Schönberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM, Scheller J.   +7 more
europepmc   +5 more sources

Investigation of IL-35 and IL-39, New Members of the IL-12 Family, in Different Clinical Presentations of Brucellosis

Immunological Investigations, 2023
Brucellosis is significantly influenced by the interactions between the causative Brucella bacteria and host immunity. Recently identified cytokines have been described for their immunomodulatory effects in numerous inflammatory, autoimmune and infectious diseases. Some of them are new members of cytokine superfamilies, including several members of the
Pınar Hız Ellergezen, Muhammed Ali Kizmaz, Abdurrahman Simsek, Nesrin Demir, Eren Cagan, S. Haldun Bal, E. Halis Akalin, H. Barbaros Oral, Ferah Budak   +8 more
openaire   +4 more sources

Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation [PDF]

Respiratory Research, 2011
Background While the presence of the chitinase-like molecule YKL40 has been reported in COPD and asthma, its relevance to inflammatory processes elicited by cigarette smoke and common environmental allergens, such as house dust mite (HDM), is not well ...
Coyle Anthony J, Jordana Manel, Bauer Carla MT, Botelho Fernando M, Nikota Jake K, Humbles Alison A, Stampfli Martin R   +6 more
doaj   +3 more sources

Human neutrophils activated by TLR8 agonists, with or without IFNγ, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39 [PDF]

Journal of Leukocyte Biology, 2020
Abstract The IL-12 family of cytokines plays crucial functions in innate and adaptive immunity. These cytokines include heterodimers sharing distinct α (IL-12A, IL-23A, and IL-27A) with two β (IL-12B and Epstein-Barr virus induced gene 3 [EBI3]) chains, respectively, IL-12 (IL-12B plus IL-12A) and IL-23 (IL-12B plus IL-23A) sharing IL ...
Cassatella, Marco A, Gardiman, Elisa, Arruda-Silva, Fabio, Bianchetto-Aguilera, Francisco, Gasperini, Sara, Bugatti, Mattia, Vermi, William, Larousserie, Frederique, Devergne, Odile, Tamassia, Nicola   +9 more
core   +5 more sources

Low levels of serum IL-39 are associated with autoimmune thyroid disease. [PDF]

J Clin Lab Anal, 2022
AbstractBackgroundInterleukin (IL)‐39 is a novel member of IL‐12 cytokine family, but its role in autoimmune thyroid diseases (AITD) is unclear. The aim of the present study was to determine serum levels of IL‐39 in Hashimoto's thyroiditis (HT) and Graves' disease (GD) patients.MethodsA total of 48 patients with HT, 50 patients with GD, and 45 healthy ...
Weng L, Huang G, Gong L, Xu J, Mao Y, Li Y, Li M.   +6 more
europepmc   +4 more sources

IL-39 in the IL-23/IL-12 axis of psoriasis

Journal of Dermatological Treatment
Omar Raheel, Christiaan Noot, Steven R. Feldman, Amy McMichael   +3 more
doaj   +3 more sources

IL-39/IL-39R Signaling Drives Acute Graft-versus-Host Disease by Promoting Pathogenic T-Cell Responses 2259690

The Journal of Immunology
Abstract Introduction Acute graft-versus-host disease (aGVHD) remains a life-threatening complication of allogeneic hematopoietic cell transplantation. Among IL-12 family cytokines, the newly identified IL-39, composed of IL-23p19 and EBI3, ligands IL-39 receptor, a complex of IL-23Rα and gp130.
Denggang Fu, Michael Hendrix, Kaipo Yang, Allison Pugel, Qiao Cheng, Yongxia Wu, Xue-Zhong Yu   +6 more
openaire   +2 more sources