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Balb/c mice deficient in IL-4 production present severe carditis and low parasitism upon infection with Trypanosoma cruzi

, 2000
Kátia Nunes da Silva, Ricardo Santana de Lima, Milena Botelho Pereira Soares, Ricardo Ribeiro dos Santos   +3 more
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Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor

The Journal of Immunology, 1991
Abstract Although numerous in vitro studies have demonstrated that cytokines are involved in the generation of alloreactive effector cells, the role of these regulatory substances in vivo is less well defined. We have recently cloned and expressed cDNAs encoding both membrane bound and soluble forms of the murine IL-4R.
W C, Fanslow, K N, Clifford, L S, Park, A S, Rubin, R F, Voice, M P, Beckmann, M B, Widmer   +6 more
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An alternative splice variant of human IL-4, IL-4 δ 2, inhibits IL-4-stimulated T cell proliferation

The Journal of Immunology, 1996
Abstract Alternative splicing of mRNA can generate protein isoforms that are preferentially expressed in different tissues or during different states of cell differentiation or activation. Protein isoforms may have different functions.
S P, Atamas, J, Choi, V V, Yurovsky, B, White   +3 more
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Probabilistic Regulation of IL-4 Production

Journal of Clinical Immunology, 2005
Among a population of uniformly differentiated TH(2) cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene.
Liying, Guo, Jane, Hu-Li, William E, Paul   +2 more
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Interleukin-4 (IL-4) Pathway

Science's STKE, 2005
Interleukin-4 (IL-4) is a cytokine produced by T H 2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between
Ann, Kelly-Welch, Erica M, Hanson, Achsah D, Keegan   +2 more
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Interleukin (IL) 4, the cytokine that isn't there: reactivity of IL-4 antibodies with cells in IL-4 -/- mice.

Transplantation, 1997
We analyzed cytokine expression in recipient spleens and cardiac allografts placed in mice that were unable to synthesize interleukin (IL)-4 due to disruption of the IL-4 gene (IL-4 -/-) and in wild-type (IL-4 +/+) mice. Polyclonal BL-4P and monoclonal 11B11, 1D11, and 24G2 anti-IL-4 antibodies were used to detect cell-surface and cytoplasmic antigens ...
P L, Mottram, L J, Purcell, W R, Han, J, Maguire, A N, Stein-Oakley   +4 more
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