Results 151 to 160 of about 1,576,668 (338)
Effect of mRNA transcription inhibitor on IL-6 induced increase in Caco-2 TJ permeability.
, 2014 (A) IL-6 caused a time-dependent increase in claudin-2 mRNA expression as assessed by real-time PCR (n = 8 ...
Shuhong Guo (541572) +6 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation [PDF]
, 2007 Dendritic cells (DC) are sentinels of the immune system that display an extraordinary capacity to present antigen to naïve T cells and initiate immune responses.
Roghanian, Ali
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Efficacy and Safety of Biologics in Polymyalgia Rheumatica: A Retrospective Study
Rheumatology and TherapyIntroduction The study aimed to determine the efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in the treatment of polymyalgia rheumatica (PMR) complicated by rheumatoid arthritis (RA).
Naoaki Ohkubo +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
针刺研究, 2017 Objective To observe the effect of warm needle moxibustion(WNM)on knee-joint swelling and expression of sirtuin 1(SIRT 1,a classⅢ histone/protein deacetylase)and nuclear factorκB(NF-κB)in synovial tissue in rats with rheumatoid arthritis(RA).Methods ...
CAI Guo-wei, LI Jia, LI Jing
doaj
Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties
, 2015 This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539) +35 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source