Results 251 to 260 of about 79,846,493 (299)

Interleukin 7 (IL-7) Receptor-Specific Cell Killing by DAB₃₈₉IL-7:  A Novel Agent for the Elimination of IL-7 Receptor Positive Cells

Bioconjugate Chemistry, 1998
Interleukin 7 (IL-7) induces the proliferation of B cell progenitors in long-term bone marrow cultures, promotes the growth of resting fetal and adult thymocytes, and costimulates mature human T cell proliferation. IL-7 also induces cell growth in hematologic malignancies such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute ...
E B, Sweeney, F M, Foss, J R, Murphy, J C, vanderSpek   +3 more
openaire   +2 more sources

B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.

The Journal of Immunology, 1994
Abstract IL-7 was originally reported as a cytokine produced by stromal cells which supports pre-B cell proliferation in vitro. To determine whether human B cells secrete IL-7 and express IL-7R we studied a wide panel of B cell lines (CLS).
D, Benjamin, V, Sharma, T J, Knobloch, R J, Armitage, M A, Dayton, R G, Goodwin   +5 more
openaire   +2 more sources

A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment

Journal of Immunological Methods, 2010
IL-7 is a crucial cytokine for T cell hematopoiesis and peripheral homeostasis which by signaling through its receptor alpha chain (CD127) is essential for inducing T cell proliferation and survival. Since the specific CD127 alpha chain is found in a soluble state (sCD127) and at a high level in plasma (ng/mL), it is important to develop a sensitive ...
Janot-Sardet, Caroline, Assouline, Brigitte, Cheynier, Rémi, Morre, Michel, Beq, Stéphanie   +4 more
openaire   +3 more sources

IL-7 and TSLP receptors: twisted sisters

Blood, 2014
In this issue of Blood, Shochat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP), resulting in a novel dimerization mechanism that drives acute lymphoblastic leukemias.
openaire   +2 more sources

Reconstitution of a functional interleukin (IL)‐7 receptor demonstrates that the IL‐2 receptor γ chain is required for IL‐7 signal transduction

European Journal of Immunology, 1995
AbstractThe interleukin (IL)‐2 receptor γ chain has recently been shown to be a component of the IL‐7 and IL‐4 receptors. Using a transient transfection assay and the trans‐activation of reporter gene constructs which are under the control of cytokine‐responsive promoter elements, we have studied signal transduction through the IL‐7 receptor (IL‐7R ...
S E, Ziegler, K K, Morella, D, Anderson, N, Kumaki, W J, Leonard, D, Cosman, H, Baumann   +6 more
openaire   +2 more sources

Complexed soluble IL-7 receptor α and IL-7 increase IL-7-mediated proliferation and viability of CD8+ T-cells in vitro

Cellular Immunology, 2015
Many soluble cytokine receptors inhibit cytokine bioactivity, while others prolong ligand activity. The biological role of an endogenous soluble form of IL-7Rα, or its therapeutic effects on CD8(+) T-cells are unknown. We demonstrate that recombinant IL-7Rα-Fc, when pre-incubated with IL-7, enhances IL-7-induced CD8(+) T-cell proliferation and ...
Sandra, Côté, Julie, Matte, Subash, Sad, Jonathan B, Angel, Angela M, Crawley   +4 more
openaire   +2 more sources

Expression and Function of IL-7 Receptors in Marrow Stromal Cells

Leukemia & Lymphoma, 2004
IL-7 was first isolated in 1988, when its role in early B lymphocyte development was noted [1-3]. It soon became apparent that IL-7 is a "stromal cytokine" produced by a variety of stromal tissues including those in bone marrow and thymus [4-10]. The production of IL-7 by bone marrow stromal cells is thought to be essential for early B lymphocyte ...
Manoj, Pillai, Beverly, Torok-Storb, Mineo, Iwata   +2 more
openaire   +2 more sources

IL-7 receptor is present on human microvascular endothelial cells

Immunology Letters, 2003
Interleukin-7 (IL-7) is a pleiotropic, non-redundant cytokine crucial for development of B and T lymphocytes. The cellular response to IL-7 is triggered by binding of the cytokine to its receptor, IL-7R. Until now the expression of the receptor was evidenced only in lymphoid and myeloid cell lineages.
Dus, D., Krawczenko, A., Zalecki, P., Paprocka, M., Wiedlocha, A., Goupille, C., Kieda, C.   +6 more
openaire   +3 more sources