Improving thymus implantation for congenital athymia with interleukin‐7 [PDF]
Clinical & Translational Immunology, 2023 Objectives Thymus implantation is a recently FDA‐approved therapy for congenital athymia. Patients receiving thymus implantation develop a functional but incomplete T cell compartment.
Hyunjung Min +6 more
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Interleukin-7 enhances in vitro development and blastocyst quality in porcine parthenogenetic embryos [PDF]
Frontiers in Veterinary Science, 2022 Interleukin-7 (IL-7), a vital factor that affects cell development, proliferation, and survival, plays an important role in oocyte maturation. However, its role in embryonic development remains unknown.
Dongjin Oh +21 more
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The Role of Interleukin-7 in the Formation of Tertiary Lymphoid Structures and Their Prognostic Value in Gastrointestinal Cancers [PDF]
Journal of Immunotherapy and Precision Oncology, 2022 Immunotherapies for the treatment of solid tumors continue to develop in preclinical and clinical research settings. Unfortunately, for many patients the tumor fails to respond or becomes resistant to therapies such as checkpoint inhibitors (CPIs ...
Michael Brandon Ware +6 more
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Potential of interleukin-7 in sepsis as a biomarker and therapeutic agent: a narrative review [PDF]
Frontiers in MedicineObjectiveThis study seeks to examine the dynamics of endogenous interleukin-7 (IL-7) and its associated regulatory factors in sepsis, and to elucidate the mechanisms by which exogenous IL-7 may confer therapeutic benefits.
Tong Zhang +5 more
doaj +2 more sources
Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies [PDF]
Pharmaceuticals, 2021 The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphoid cell development. The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of-function alterations in the pathway contribute to malignant transformation ...
Inge Lodewijckx, Jan Cools
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Analysis of interleukin 7 and platelet-derived growth factor BB mRNA expression as potential markers in erythema nodosum leprosum [PDF]
Dermatology Reports, 2023 Introduction: Erythema Nodosum Leprosum (ENL) is an immunological complication of leprosy characterized by acute inflammation of the skin, nerves, and other organs. Identifying laboratory parameters are important to early diagnosis of leprosy reactions.
Fitri Kadarsih Banjar +9 more
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Targeting Interleukin-7 Signalling in Ulcerative Colitis: Rationale and Emerging Clinical Evidence [PDF]
LifeUlcerative colitis (UC) remains difficult to control in a substantial proportion of patients despite an expanding range of advanced therapies. Interleukin-7 (IL-7) is a homeostatic cytokine that supports lymphocyte survival, persistence and intestinal ...
Magdalini Manti +3 more
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Interleukin-7 induces EMT to promote tumor growth and metastasis in NSCLC via Notch1/TGF-β pathway [PDF]
Scientific ReportsInterleukin 7 (IL‑7) regulates lymphangiogenesis and proliferation, inhibits apoptosis and autophagy in non‑small cell lung cancer (NSCLC). However, the role and detailed molecular mechanism of IL‑7 involved in NSCLC epithelial-to-mesenchymal transition (
Yajiao Shao +7 more
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Circulating Interleukin-7 in Human Pulmonary Arterial Hypertension [PDF]
Frontiers in Cardiovascular Medicine, 2021 Objectives: Interleukin-7 (IL-7) secures B cell maturation, regulatory T and natural killer (NK) cell survival, and homeostasis, all of which are important for beneficial immunomodulation in pulmonary arterial hypertension (PAH).
Franziska Diekmann +6 more
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Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial [PDF]
Annals of Intensive Care, 2023 Background Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival.
Thomas Daix +14 more
doaj +2 more sources