Results 21 to 30 of about 76,985,047 (293)

Investigation of Interleukin-7 Serum Levels in Patients with Osteosarcoma [PDF]

open access: yesمجله علوم پزشکی صدرا, 2019
Primary bone cancers, mainly osteosarcoma, are the most common malignancies in human musculoskeletal system. Several risk factors including inflammatory and immunologic factors have been introduced in this disease of which cytokines can be named. The aim
Hamed Fouladseresht   +3 more
doaj   +1 more source

Effect of Interleukin-7 on In Vitro Maturation of Porcine Cumulus-Oocyte Complexes and Subsequent Developmental Potential after Parthenogenetic Activation

open access: yesAnimals, 2021
Interleukin-7 (IL-7) is a cytokine essential for cell development, proliferation and survival. However, its role in oocyte maturation is largely unknown.
Dongjin Oh   +9 more
doaj   +1 more source

Interleukin 7 from maternal milk crosses the intestinal barrier and modulates T-cell development in offspring [PDF]

open access: yes, 2011
Background Breastfeeding protects against illnesses and death in hazardous environments, an effect partly mediated by improved immune function. One hypothesis suggests that factors within milk supplement the inadequate immune response of the offspring,
Andrew M Prentice   +11 more
core   +2 more sources

IL-7 producing immunotherapy improves ex vivo T cell functions of immunosenescent patients, especially post hip fracture

open access: yesHuman Vaccines & Immunotherapeutics, 2023
Following acute stress such as trauma or sepsis, most of critically ill elderly patients become immunosuppressed and susceptible to secondary infections and enhanced mortality.
Chrystel Marton   +11 more
doaj   +1 more source

Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors

open access: yesFrontiers in Immunology, 2022
BackgroundChimeric antigen receptor T (CAR-T) cell therapy has made significant advances for hematological malignancies but encounters obstacles in the treatment of solid tumors mainly due to tumor immunosuppressive microenvironment ...
Fanfan Li   +15 more
doaj   +1 more source

Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]

open access: yes, 2008
During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core   +1 more source

CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes

open access: yesFrontiers in Immunology, 2019
The common gamma chain (γc) contributes to the formation of different cytokine receptors [e.g., IL-2 receptor (IL-2R), IL-7R, and IL-15R], which are important for generation of self-reactive T-cells in autoimmune diseases, like in type 1 diabetes (T1D ...
Julia Seyfarth   +8 more
doaj   +1 more source

Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling

open access: yeseLife, 2023
Acute lymphoblastic and myeloblastic leukemias (ALL and AML) have been known to modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. However, the molecular mechanisms driving these alterations remain poorly defined.
Xing Feng   +8 more
doaj   +1 more source

Mesenchymal stem cells shuttling miR-503 via extracellular vesicles enhance glioma immune escape

open access: yesOncoImmunology, 2022
Glioma is emerging as an aggressive type of glioma characterized by invasive growth pattern and dismal oncologic outcomes. microRNAs (miRNAs) have been attracting research attention in tumorigenesis.
Xiao-Song Wang   +7 more
doaj   +1 more source

The influence of humoral factors of homeostatistic proliferation on t-regulatory cells in vitro

open access: yesБюллетень сибирской медицины, 2019
Aim. The aim of this study was the investigation of the influence of humoral factors of homeostatic proliferation IL-7 and IL-15 on T-regulatory cells in healthy donors.Materials and methods.
D. V. Shevyrev   +2 more
doaj   +1 more source

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