Results 261 to 270 of about 79,846,493 (299)

IL-7 Receptor Drives Early T Lineage Progenitor Expansion

The Journal of Immunology, 2022
Abstract IL-7 and IL-7R are essential for T lymphocyte differentiation by driving proliferation and survival of specific developmental stages. Although early T lineage progenitors (ETPs), the most immature thymocyte population known, have a history of IL-7R expression, it is unclear whether IL-7R is required at this stage. In this study,
Rafael A Paiva, Camila V Ramos, Gonçalo Leiria, Vera C Martins   +3 more
openaire   +2 more sources

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

Science, 1994
The γ chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor γ chain showed that the γ chain participates in the functional high-
M, Kondo, T, Takeshita, M, Higuchi, M, Nakamura, T, Sudo, S, Nishikawa, K, Sugamura   +6 more
openaire   +2 more sources

A Comparison of Proliferative Response to IL-7 and Expression of IL-7 Receptors in Intermediate TCR Cells of the Liver, Spleen, and Thymus

Cellular Immunology, 1996
It is well established that IL-7 supports the earliest differentiation of both T and B cells in fetal and adult life. On the other hand, mature lymphocyte subsets tend to decrease the response to IL-7 in case of T and B cells. In a recent study, NK1.1+ T cells in the thymus are also found to efficiently respond to IL-7 and express IL-7 receptors (IL-7R)
C, Miyaji, H, Watanabe, Y, Osman, Y, Kuwano, T, Abo   +4 more
openaire   +2 more sources

The Role of IL-7 and Its Receptor in B-Cell Ontogeny

1992
Interleukin-7 is a molecule that was originally identified on the basis of its ability to stimulate growth of murine pre-B cells (1). It appears to be principally a growth factor, not a differentiation factor, and has no effects on mature B cells. How early IL-7 acts in the pathway of B-lymphopoiesis has not been clearly defined; however, it is clear ...
L S, Park, P J, Morrissey, B, Davison, K, Grabstein   +3 more
openaire   +2 more sources

Origins of peripheral B cells in IL-7 receptor-deficient mice

Molecular Immunology, 2006
The interleukin 7 (IL-7) signaling pathway is critical for early lymphoid differentiation. We found dramatic perturbations in fetal liver B cell development and confirmed a complete absence of developing B cells in the adult bone marrow in mice lacking the IL-7 receptor alpha (IL-7Ralpha) gene.
David G T, Hesslein, Shu Yuan, Yang, David G, Schatz   +2 more
openaire   +2 more sources

[Molecular aspects of IL-7-IL-7 receptor system].

Nihon rinsho. Japanese journal of clinical medicine, 1992
IL-7 is a multifunctional cytokine which acts on cells such as B cells, T cells and macrophages. As the IL-7 clearly plays many important roles the in control of growth and differentiation, it is important to understand how IL-7 and IL-7 receptor (IL-7R) are expressed.
openaire   +1 more source

Disseminated Tuberculosis in an Infant with IL-7 Receptor Deficiency

Indian Journal of Pediatrics, 2023
Jing Jin, Haiguo Yu
openaire   +2 more sources

Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis

Blood, 2004
AbstractInterleukin-7 receptor (IL-7R) levels are tightly controlled during ontogeny: high on double-negative (DN) cells, absent on double-positive (DP) cells, and high once again on thymocytes undergoing positive selection. To determine if loss of IL-7–mediated survival signals in DP cells is necessary for normal antigen-specific selection, we created
Munitić, Ivana, Williams, J.A., Yang, Y., Dong, B., Lucas, P.J., El Kassar, N., Gress, R.E., Ashwell, J.D.   +7 more
openaire   +2 more sources

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

Nature, 1998
To generate the full diversity of antibody heavy-chain genes, hundreds of dispersed germline V segments must undergo recombination following D-J segment joining. Here we report that this process is regulated by the alpha-chain of the receptor for interleukin-7, a cytokine that stimulates B-cell lymphopoiesis.
A E, Corcoran, A, Riddell, D, Krooshoop, A R, Venkitaraman   +3 more
openaire   +2 more sources

Immunophenotype of HIV+ patients during CD4 cell-monitored treatment interruption: role of the IL-7/IL-7 receptor system

AIDS, 2006
To investigate immunological changes during CD4-guided therapy interruption in HIV(+) patients who suspended HAART.Seventeen patients aged > 18 years, who had received HAART for at least 12 months, and had a pre-interruption CD4+ cell count > 500 cells/microl, interrupted treatment. Median nadir CD4(+) cell count was 288 cells/microl.
E. Nemes, E. Lugli, M. Nasi, R. Ferraresi, M. Pinti, R. Bugarini, V. Borghi, F. Prati, R. Esposito, A. Cossarizza, C. Mussini   +10 more
openaire   +3 more sources