Results 191 to 200 of about 10,918,391 (231)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
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IL-8 and cancer prognosis on immunotherapy

Nature Medicine, 2020
Interleukin-8, produced by intratumoral and circulating myeloid cells, correlates with an immunosuppressive myeloid-enriched tumor microenvironment and adverse cancer prognosis.
Ziad Bakouny, Toni K. Choueiri
openaire   +2 more sources

Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer

Gynecologic Oncology, 2006
In an ongoing effort to identify diagnostic ovarian cancer biomarkers, SEREX (serological analysis of recombinant cDNA expression libraries) technique was employed resulting in detection of 20 known genes, nine ESTs and one novel sequence. Interleukin-8 (IL-8) was one of ovarian cancer-associated antigens identified by SEREX screening. The objective of
Anna E, Lokshin, Mathew, Winans, Douglas, Landsittel, Adele M, Marrangoni, Lyudmila, Velikokhatnaya, Francesmary, Modugno, Brian M, Nolen, Elieser, Gorelik   +7 more
openaire   +2 more sources

The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours

Cytokine, 2010
Inflammatory mediators influence tumour progression. IL-8 has been shown to have pro-angiogenic, mitogenic and motogenic effects and several studies have demonstrated the expression of IL-8 by various human pancreatic cancer cell lines.The expression of IL-8 and IL-8 receptors was studied in 52 pancreatic adenocarcinomas and 52 pancreatic ...
Farah, Hussain, Jayson, Wang, Raida, Ahmed, Stephanie K, Guest, Eric W-F, Lam, Gordon, Stamp, Mona, El-Bahrawy   +6 more
openaire   +2 more sources

Targeting IL-8 in colorectal cancer

Expert Opinion on Therapeutic Targets, 2012
Colorectal cancer is the leading cause of death from gastrointestinal malignancy in the US. Chemokines and their receptors are being recognized as key regulators of cancers and increasingly as therapeutic targets for metastatic cancers, including colorectal cancer.
Yan, Ning, Heinz-Josef, Lenz
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IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors

The Journal of Immunology, 1995
Abstract IL-8 is a potent proinflammatory cytokine that has a key role in the recruitment and activation of neutrophils during inflammation. IL-8 reacts with neutrophils via two distinct types of IL-8-R. Receptor-specific Abs were raised against peptides derived from the first extracellular domain of each IL-8-R. Anti-IL-8-R1 and anti-
M E, Hammond, G R, Lapointe, P H, Feucht, S, Hilt, C A, Gallegos, C A, Gordon, M A, Giedlin, G, Mullenbach, P, Tekamp-Olson   +8 more
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Specific binding of IL-8 to rabbit α -macroglobulin modulates IL-8 function in the lung

Inflammation Research, 2000
The purpose of this study was to compare chemotactic activity of IL-8 alone with that of IL-8 reacted with rabbit alpha-macroglobulins (alphaM) in vivo.Initially the binding of recombinant human IL-8 (rhIL-8) to rabbit alphaM was studied. 125I-labeled rhIL-8 was incubated with alphaM, and electrophoresed on native 5% gels or SDS-polyacrylamide 4-20 ...
A, Kurdowska, N, Fujisawa, B, Peterson, F K, Carr, J M, Noble, S M, Alden, E J, Miller, M, Teodorescu   +7 more
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Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor

The Journal of Immunology, 1995
Abstract We investigated the regulatory mechanism of the expression of IL-8R, IL-8R type A (IL-8RA), and IL-8R type B (IL-8RB) on human neutrophils by IL-8. The expression of IL-8RA/B was analyzed by flow cytometry using mAb specific for each receptor. IL-8 down-modulated > 90% of IL-8RA and IL-8RB expression within 5 min.
A, Chuntharapai, K J, Kim
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IL-8 degradation byPorphyromonas gingivalisproteases

Microbial Pathogenesis, 1999
Gingival epithelial cells are the primary barrier to infection by periodontal pathogens. The production of chemotactic cytokines, including interleukin-8 (IL-8), is one mechanism the host uses in response to infection. In this study it was found that both gingival and oral epithelial cells produced IL-8, but after infection with the periodontal ...
J, Zhang, H, Dong, S, Kashket, M J, Duncan   +3 more
openaire   +2 more sources

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2014
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openaire   +1 more source