Results 261 to 270 of about 1,701,290 (294)

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors.

The Journal of Immunology, 1995
Abstract IL-8 is a potent proinflammatory cytokine that has a key role in the recruitment and activation of neutrophils during inflammation. IL-8 reacts with neutrophils via two distinct types of IL-8-R. Receptor-specific Abs were raised against peptides derived from the first extracellular domain of each IL-8-R. Anti-IL-8-R1 and anti-IL-
M E, Hammond, G R, Lapointe, P H, Feucht, S, Hilt, C A, Gallegos, C A, Gordon, M A, Giedlin, G, Mullenbach, P, Tekamp-Olson   +8 more
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Targeting IL-8 in colorectal cancer

Expert Opinion on Therapeutic Targets, 2012
Colorectal cancer is the leading cause of death from gastrointestinal malignancy in the US. Chemokines and their receptors are being recognized as key regulators of cancers and increasingly as therapeutic targets for metastatic cancers, including colorectal cancer.
Yan, Ning, Heinz-Josef, Lenz
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IL-8 and cancer prognosis on immunotherapy

Nature Medicine, 2020
Interleukin-8, produced by intratumoral and circulating myeloid cells, correlates with an immunosuppressive myeloid-enriched tumor microenvironment and adverse cancer prognosis.
Ziad Bakouny, Toni K. Choueiri
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Expression and one-step ion-exchange purification of (AAR)IL-8 (human IL-8 receptor antagonist)

Protein Expression and Purification, 2005
Interleukin-8 (IL-8) is C-X-C chemokine, which is produced by a variety of cells. IL-8 plays an important role in the inflammatory response and may be a therapeutic target for some inflammatory diseases. To develop an IL-8 receptor antagonist, (AAR)IL-8 (IL-8 receptor antagonist) was constructed and successfully expressed in Escherichia coli. (AAR)IL-8
Dengyong, Hou, Zhen, Yan, Jihong, Shi, Wei, Han, Yingqi, Zhang   +4 more
openaire   +2 more sources

IL-8 mRNA expression and IL-8 production by acute myeloid leukemia cells.

Leukemia, 1993
Purified leukemic cells from 30 acute myeloid leukemia (AML) cases at diagnosis were investigated for the presence of interleukin 8 (IL-8) mRNA by Northern blot analysis. IL-8 specific transcripts were detected in uncultured blasts in 14/30 cases, 10/14 from patients with M4-M5 and 4/14 from cases with M0-M3 morphology.
VINANTE, Fabrizio, RIGO, Antonella, Vincenzi Carlo, RICETTI, Maria Maddalena, Marrocchella Raffaella, CHILOSI, Marco, CASSATELLA, Marco Antonio, Bonazzi Luisa, PIZZOLO, Giovanni   +8 more
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The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours

Cytokine, 2010
Inflammatory mediators influence tumour progression. IL-8 has been shown to have pro-angiogenic, mitogenic and motogenic effects and several studies have demonstrated the expression of IL-8 by various human pancreatic cancer cell lines.The expression of IL-8 and IL-8 receptors was studied in 52 pancreatic adenocarcinomas and 52 pancreatic ...
Farah, Hussain, Jayson, Wang, Raida, Ahmed, Stephanie K, Guest, Eric W-F, Lam, Gordon, Stamp, Mona, El-Bahrawy   +6 more
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NAP-1/IL-8 in Rheumatoid Arthritis

1991
Neutrophil activating peptide 1, or interleukin-8 (NAP-1, IL-8), was isolated almost simultaneously by several groups as a neutrophil chemotactic or activating peptide from supernatants of endotoxin stimulated monocytes (1–5). The major form with 72 amino acids, and an approximate molecular weight of 8.4 kD, has since been shown to have activities on a
I J, Lindley, M, Ceska, P, Peichl
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Specific binding of IL-8 to rabbit α -macroglobulin modulates IL-8 function in the lung

Inflammation Research, 2000
The purpose of this study was to compare chemotactic activity of IL-8 alone with that of IL-8 reacted with rabbit alpha-macroglobulins (alphaM) in vivo.Initially the binding of recombinant human IL-8 (rhIL-8) to rabbit alphaM was studied. 125I-labeled rhIL-8 was incubated with alphaM, and electrophoresed on native 5% gels or SDS-polyacrylamide 4-20 ...
A, Kurdowska, N, Fujisawa, B, Peterson, F K, Carr, J M, Noble, S M, Alden, E J, Miller, M, Teodorescu   +7 more
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Depletion of B lymphocytes in rheumatoid arthritis patients modifies IL-8-anti-IL-8 autoantibody network

Clinical Immunology, 2009
Cytokines and chemokines are key regulatory molecules involved in rheumatoid arthritis (RA). B-cell depletion therapy improves RA clinically but its mechanism is not completely understood. One possible mechanism for this therapy is the modification of the proinflammatory cytokine homeostasis of RA.
Zohar, Keren, Yolanda, Braun-Moscovici, Doron, Markovits, Alexander, Rozin, Menahem, Nahir, Alexandra, Balbir-Gurman, Doron, Melamed   +6 more
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Biology of IL‐8‐Induced Stem Cell Mobilization

Annals of the New York Academy of Sciences, 1999
Abstract: The CXC chemokine interleukin‐8 (IL‐8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys.
Fibbe, W.E., Pruijt, J.F.M., Velders, G.A., Opdenakker, G., Kooyk, Y. van, Figdor, C.G., Willemze, R.   +6 more
openaire   +5 more sources