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Combinatorial Chemistry and High Throughput Screening, 2022
Background: Interleukin-12 receptor (IL12R) is a type I cytokine receptor that can promote hematopoiesis and regulate innate and adaptive immunity. It binds with the IL12 ligand, which activates the IL-12 signaling pathway that triggers hematopoietic progenitor cell proliferation and differentiation process. The structure of IL12:IL12R complex is not
Geeta Rai, Sakshi Singh
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Background: Interleukin-12 receptor (IL12R) is a type I cytokine receptor that can promote hematopoiesis and regulate innate and adaptive immunity. It binds with the IL12 ligand, which activates the IL-12 signaling pathway that triggers hematopoietic progenitor cell proliferation and differentiation process. The structure of IL12:IL12R complex is not
Geeta Rai, Sakshi Singh
exaly +3 more sources
Improved Intratumoral Penetration of IL12 Immunocytokine Enhances the Antitumor Efficacy
Frontiers in Immunology, 2022 Tumor-targeting antibody (Ab)-fused cytokines, referred to as immunocytokines, are designed to increase antitumor efficacy and reduce toxicity through the tumor-directed delivery of cytokines. However, the poor localization and intratumoral penetration of immunocytokines, especially in solid tumors, pose a challenge to effectively stimulate antitumor ...
Wook Kim, Yong-Sung Kim, Keunok Jung
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Is IL12 Necessary in Experimental Hypersensitivity Pneumonitis?
International Journal of Experimental Pathology, 2002 Summary. Inhalation of Saccharopolyspora rectivirgula (SR) can cause the disease Farmer's Lung, a classic example of hypersensitivity pneumonitis. Th1, but not Th2, cell lines can adoptively transfer experimental hypersensitivity pneumonitis (EHP). Substantial amounts of IL12 appear in bronchoalveolar lavage fluid (BALF) after a single intratracheal ...
Mark Schuyler
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IL12 in Candida albicans infections
Research in Immunology, 1995Cell-mediated and humoral immune responses are functions of distinct subsets of CD4+ cells termed Thl and Th2 cells, respectively (Mosmann and Coffman, 1989). In mucosal colonization and systemic infection of mice with the opportunistic fungal pathogen Candida albicans, a commensal for most healthy humans, Thl cells mediate phagocytedependent ...
ROMANI, Luigina +5 more
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Detection of IL12/23p40 via PET Visualizes Inflammatory Bowel Disease
Journal of Nuclear Medicine, 2023Inflammatory bowel disease (IBD), which includes both Crohn disease and ulcerative colitis, is a relapsing inflammatory disease of the gastrointestinal tract. Long-term chronic inflammatory conditions elevate the patient's risk of colorectal cancer (CRC). Currently, diagnosis requires endoscopy with biopsy.
Farzaneh, Rezazadeh +7 more
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Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy
Clinical Cancer Research, 2019Abstract Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal ...
H. Kim Lyerly +2 more
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Granulomatous lymphadenitis revealing a deficiency in receptor IL12
2017Lettre à la ...
Kamoun, Fatma +5 more
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Role of IL12 Family in Regulation of Antitumor Immune Response
2009The efficacy of immune therapy is partially dependent upon the tumor microenvironment. This microenvironment could either promote or demote tumor growth. Cytokines, which are secreted either by tumor, immune, or stromal cells, are key players that govern the outcome of this microenvironment.
Denada Dibra, Shulin Li
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