Results 121 to 130 of about 178,409 (303)
Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2
Rheumatology &Autoimmunity, EarlyView.Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li +5 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Titanium dioxide (TiO2), used as a food additive (labeled E171 in Europe), was withdrawn from the European market in 2022. The E171 toxicity mechanism involves its uptake, oxidative stress, DNA damage, and inflammation. It has been hypothesized that the TiO2 accumulation nanoparticles (NPs) or E171 triggers tissue damage, and some studies have
Carmen Ximena Martínez‐Escutia +3 more
wiley +1 more source
Veterinary Record, EarlyView.Abstract Background Most studies on colic surgery outcome focus on short‐term survival and complications. Long‐term outcomes, particularly post‐discharge morbidity, are poorly characterised despite their relevance. No standardised system has previously integrated both short‐ and long‐term postoperative complications with survival outcomes.
Marco Gandini, Gessica Giusto
wiley +1 more source
Integrative Zoology, EarlyView.This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng +19 more
wiley +1 more source
Journal of Digestive Diseases, EarlyView.Transcolonic endoscopic appendectomy (TEA) is a minimally invasive, single‐step “two‐in‐one” procedure for recurrent appendicitis with appendiceal orifice lesions. It enables precise resection of both appendix and associated lesions, with a novel closure method reducing operative time and improving safety.
Hao Wu +7 more
wiley +1 more source
Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia
Journal of Medical Imaging and Radiation Oncology, EarlyView.ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes +2 more
wiley +1 more source