Results 41 to 50 of about 56,332 (214)

Comparison of capture-based mtDNA sequencing performance between MGI and illumina sequencing platforms in various sample types

BMC Genomics
Background Mitochondrial genome abnormalities can lead to mitochondrial dysfunction, which in turn affects cellular biology and is closely associated with the development of various diseases.
Zehui Feng, Fan Peng, Fanfan Xie, Yang Liu, Huanqin Zhang, Jing Ma, Jinliang Xing, Xu Guo   +7 more
doaj   +1 more source

Transcriptome dataset for comparative analysis of differentially expressed genes between wild type and transgenic potato plants overexpressing Nuclear Factor Y subunit A7

Data in Brief
Nuclear Factor Y (NF-Y) is divided into three different types of subunits, A, B, and C. NF-Ys play crucial roles in plants for controlling gene expression associated with various developmental processes and abiotic stresses, but it is mostly unknown the ...
Bimpe Suliyat Azeez, Dool-Yi Kim, Jong-Kuk Na   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Comparative assessment of the Sikun 2000 sequencing platform for whole genome sequencing

Scientific Reports
DNA sequencing technology has significantly advanced over the past five decades, particularly with the introduction of next-generation sequencing (NGS) platforms like Illumina’s NovaSeq.
Keya Cai, Sibin Li, Meng Pan, Hui Lu, Liang Wang, Shengquan Fang, Lingzhi Gou, Jiang Tang, Yan Kong, Li Zhao, Yongyong Ren   +10 more
doaj   +1 more source

The complete mitochondrial genome and phylogenetic position of Triplophysa qiubeiensis (Cypriniformes: Nemacheilidae)

Mitochondrial DNA. Part B. Resources
In this study, the complete mitochondrial genome of Triplophysa qiubeiensis (Cypriniformes: Nemacheilidae) was determined using the Illumina Novaseq 6000 platform.
Yizhu Chen, Yuansheng Zhu, Yue Wang, Dengqiang Wang   +3 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Comparative performance of the GenoLab M and NovaSeq 6000 sequencing platforms for transcriptome and LncRNA analysis

BMC Genomics, 2021
Background GenoLab M is a recently established next-generation sequencing platform from GeneMind Biosciences. Presently, Illumina sequencers are the globally leading sequencing platform in the next-generation sequencing market. Here, we present the first
Yongfeng Liu, Ran Han, Letian Zhou, Mingjie Luo, Lidong Zeng, Xiaochao Zhao, Yukun Ma, Zhiliang Zhou, Lei Sun   +8 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The first report on complete mitochondrial genome of Murina yushuensis (Chiroptera: Vespertilionidae) and its phylogenetic analysis

Mitochondrial DNA. Part B. Resources
In this study, a complete mitochondrial genome of Murina yushuensis, sampled from Sichuan, China, was sequenced using the Illumina NovaSeq 6000 S4 platform.
Hongyan Shi, Taihan Huang, Xindan Fan, Xiaoyun Wang, Wenhua Yu, Xiaoxue Fu, Yi Wu   +6 more
doaj   +1 more source