Results 101 to 110 of about 411,747 (263)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Full-length 16S rRNA gene sequencing by PacBio improves taxonomic resolution in human microbiome samples

BMC Genomics
Background Sequencing variable regions of the 16S rRNA gene (≃300 bp) with Illumina technology is commonly used to study the composition of human microbiota.
Elena Buetas, Marta Jordán-López, Andrés López-Roldán, Giuseppe D’Auria, Llucia Martínez-Priego, Griselda De Marco, Miguel Carda-Diéguez, Alex Mira   +7 more
doaj   +1 more source

Comprehensive transcriptome analysis of sika deer antler using PacBio and Illumina sequencing. [PDF]

Sci Rep, 2022
Zhang R, Dong Y, Xing X.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Comparative analysis of illumina and oxford nanopore sequencing platforms for 16S rRNA profiling of respiratory microbial communities

Scientific Reports
The respiratory microbiome plays a crucial role in health and disease, necessitating accurate characterization through high-throughput sequencing technologies.
Guillem Macip, Alba Soler-Comas, Andrea Palomeque, Ana Motos, Blanca Llonch, Joan Canseco-Ribas, Leticia Bueno-Freire, Davide Calabretta, Kasra Kiarostami, Roberto Cabrera, Miquel Ferrer, Antoni Torres, Laia Fernandez-Barat   +12 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

MOESM9 of Integrated analysis of 454 and Illumina transcriptomic sequencing characterizes carbon flux and energy source for fatty acid synthesis in developing Lindera glauca fruits for woody biodiesel

, 2017
Zixin Lin, Jiyong An, Jia Wang, Jun Niu, Chao Ma, Libing Wang, Guanshen Yuan, Lingling Shi, Lili Liu, Jinsong Zhang, Zhixiang Zhang, Ji Qi, Shanzhi Lin   +12 more
openalex   +1 more source

PacBio and Illumina MiSeq Amplicon Sequencing Confirm Full Recovery of the Bacterial Community After Subacute Ruminal Acidosis Challenge in the RUSITEC System

, 2020
Melanie Brede, Theresa Orton, Beate Pinior, Franz‐Ferdinand Roch, Monika Dzieciol, Benjamin Zwirzitz, Martin Wagner, G. Breves, Stefanie U. Wetzels   +8 more
openalex   +1 more source

De novo assembly and characterization of bark transcriptome using Illumina sequencing and development of EST-SSR markers in rubber tree (Hevea brasiliensis Muell. Arg.) [PDF]

, 2012
Dejun Li, Zhi Deng, Bi Qin, Xianghong Liu, Zhonghua Men   +4 more
openalex   +1 more source

Systematic Genomic Surveillance of SARS-CoV-2 Virus on Illumina Sequencing Platforms in the Slovak Republic-One Year Experience. [PDF]

Viruses, 2022
Rusňáková D, Sedláčková T, Radvák P, Böhmer M, Mišenko P, Budiš J, Bokorová S, Lipková N, Forgáčová-Jakúbková M, Sládeček T, Sitarčík J, Krampl W, Gažiová M, Kaliňáková A, Staroňová E, Tichá E, Vrábľová T, Ševčíková L, Kotvasová B, Maďarová L, Feiková S, Beňová K, Reizigová L, Onderková Z, Ondrušková D, Loderer D, Škereňová M, Danková Z, Janíková K, Halašová E, Nováková E, Turňa J, Szemes T.   +32 more
europepmc   +1 more source