Results 101 to 110 of about 677,734 (335)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Analysis of the utilization of supplementary illustrations: An example of the selected teaching units from the fifth grade geography textbook (Republic of Serbia) [PDF]

open access: yesGeographica Pannonica, 2014
The textbook is one of the elementary teaching aids. It is a very efficient aid utilized to transfer information of the instructional content. Illustrations are a part of the didactic apparatus, contributing to apparentness.
Đukičin Smiljana   +3 more
doaj  

Market Implied Probability Distributions and Bayesian Skew Estimation [PDF]

open access: yesarXiv, 2009
We review and illustrate how the volatility smile translates into a probability distribution, the market-implied probability distribution representing believes priced in. The effects of changes in the smile are examined. Special attention is given to the effects of slope, which might appear at first counter-intuitive.
arxiv  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

A State-Dependent Updating Period For Certified Real-Time Model Predictive Control [PDF]

open access: yesarXiv, 2015
In this paper, a state-dependent control updating period framework is proposed that leads to real-time implementable Model Predictive Control with certified practical stability results and constraints satisfaction. The scheme is illustrated and validated using new certification bound that is derived in the case where the Fast Gradient iteration is used
arxiv  

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