Results 51 to 60 of about 7,843 (191)

Inhaled iloprost for severe pulmonary hypertension

Background Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension. Methods We compared
Nikkho S, Simonneau G, Ewert R, Siedentop H, Olschewski H, Ghofrani HA, Kiely DG, Sitbon O, Manes A, Naeije R, Speich R, Seeger W, Rubin LJ, Popov W, Winkler J, Behr J, Hoeper MM, Higenbottam T, Galie N   +18 more
core   +5 more sources

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Iloprost reduces colonic injury in ischemic colitis in rats Iloprosta reduz o dano colônico na colite isquêmica em ratos

Acta Cirúrgica Brasileira, 2011
PURPOSE: Evaluate the effects of iloprost administration in the early period of ischemic colitis and the mechanism that how these effects develop. METHODS: Thirty two Wistar albino female rats with an average weight of 220g were divided into four groups ...
Oguzhan Karatepe, Affan Cakir, Orçun Unal, Muharrem Battal, Gokhan Adas, Gülcin Kamali, Ahu Kemik, Timucin Aydin, Sedat Kamali, Servet R Karahan, Murat Aksoy   +10 more
doaj   +1 more source

Maternal and perinatal outcomes of pregnant women with echocardiographically high probability of pulmonary arterial hypertension

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study aimed to describe maternal and perinatal outcomes among pregnant women with echocardiographically high probability of pulmonary arterial hypertension (PAH) managed at a quaternary center and to compare outcomes between women with and without cardiac complications (CC).
Laura Belmont‐Rojo, Rosa Hernandez‐Cruz, Ana Jimena Lopez‐Diaz, Diana Yazmin Copado‐Mendoza, Tirso Rubalcava‐Rubalcava, Mario Isaac Lumbreras‐Marquez, Maria Antonia Pijuan‐Domenech   +6 more
wiley   +1 more source

A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice

Respiratory Research, 2010
Background Metabolites of arachidonic acid such as prostacyclin (PGI2) have been shown to participate in the pathogenesis of pulmonary fibrosis by inhibiting the expression of pro-inflammatory and pro-fibrotic mediators.
Guo Zijian, Xiao Yu, Huang Kewu, Jiang Lei, Xiang Ruolan, Zhou Weixun, Liu Yong, Zhu Yuanjue, Gao Jinming   +8 more
doaj   +1 more source

Iloprost in Acute Post-kidney Transplant Atheroembolism: A Case Report of Two Successful Treatments

Frontiers in Medicine, 2020
Cholesterol embolization (CE) is a rare and alarming post-transplant complication, responsible for primary non-function (PNF) or delayed graft function (DGF).
Valeria Corradetti, Giorgia Comai, Matteo Ravaioli, Vania Cuna, Valeria Aiello, Federica Odaldi, Andrea Angeletti, Irene Capelli, Gaetano La Manna   +8 more
doaj   +1 more source

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, Volume 38, Issue 55, 1 October 2026.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source

Iloprost relaxes phenylephrine-precontracted rat aortic rings

, 2016
Iloprost is a prostacyclin analogue mainly used in the treatment of pulmonary hypertension. It is also effective for renal dysfunction during renal transplant and coronary artery bypass grafting surgery, but there have been few comparative experimental ...
Dogan, Emre, Gokalp, Osman, Cankara, Fatma Nihan, Donmez, Soner, Peker, Recep Oktay   +4 more
core   +2 more sources

Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors

Respiratory Research, 2005
Inhaled prostanoids and phosphodiesterase (PDE) inhibitors have been suggested for treatment of severe pulmonary hypertension. In catheterized rabbits with acute pulmonary hypertension induced by continuous infusion of the stable thromboxane analogue ...
Weissmann Norbert, Gall Henning, Ghofrani Hossein, Inholte Christiane, Schermuly Ralph, Weidenbach Andreas, Seeger Werner, Grimminger Friedrich   +7 more
doaj   +1 more source

Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

Respiratory Research, 2013
Background Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components
Larsson-Callerfelt Anna-Karin, Hallgren Oskar, Andersson-Sjöland Annika, Thiman Lena, Björklund Johan, Kron Josefine, Nihlberg Kristian, Bjermer Leif, Löfdahl Claes-Göran, Westergren-Thorsson Gunilla   +9 more
doaj   +1 more source