Results 1 to 10 of about 28,318 (119)
Epoprostenol as an alternative anticoagulant for pediatric aquadex therapy: a safe and feasible option [PDF]
Frontiers in PediatricsBackgroundThe Aquadex ultrafiltration system offers a low extracorporeal volume option for the pediatric population. To maintain circuit patency, it relies on conventional anticoagulation, and data on alternative anticoagulation strategies are limited ...
Buria Naeem +4 more
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Prostacyclin Regulation of Allergic Inflammation
Biomedicines, 2022 Prostacyclin is a metabolic product of the cyclooxygenase pathway that is constitutively expressed and can be induced during inflammatory conditions. While prostacyclin and its analogs have historically been considered effective vasodilators and used in ...
Kunj Patel, R. Stokes Peebles
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Cardiology Journal, 2021 Prostacyclin and analogues are successfully used in the treatment of pulmonary arterial hypertension (PAH) due to their vasodilatory effect on pulmonary arteries.
Sylwester P. Rogula +4 more
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Experimental Physiology, 2023 Platelet activation may contribute to age‐related cerebrovascular dysfunction by interacting with the endothelial cells that regulate the response to vasodilatory stimuli.
Adam T. Corkery +8 more
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Respiratory Medicine Case Reports, 2022 The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except for lung transplantation when prostacyclin infusion is ineffective.
Mizuki Momoi +7 more
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Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration
Advanced Science, 2023 It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are both known to induce muscle regeneration, the molecular signals that help trigger muscle ...
Lanfang Luo +14 more
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Prostanoid Metabolites as Biomarkers in Human Disease
Metabolites, 2022 Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2) together form the prostanoid family of lipid mediators. As autacoids, these five primary prostanoids propagate intercellular signals and are involved in many physiological
Helena Idborg, Sven-Christian Pawelzik
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Increased expression and catalytic activity of prostacyclin synthase after simvastatin application to human umbilical vein endothelial cells [PDF]
Archives of Biological Sciences, 2020 In addition to lowering blood cholesterol levels, statins are known to exert antiplatelet effects. One of the key factors contributing to the antiplatelet effects of statins includes the upregulation of prostacyclin (PGI2) level.
Cho Sun-Ah, Lee Su-Jun
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Prostacyclin analogue beraprost inhibits cardiac fibroblast proliferation depending on prostacyclin receptor activation through a TGF β-Smad signal pathway. [PDF]
PLoS ONE, 2014 Previous studies showed that prostacyclin inhibited fibrosis. However, both receptors of prostacyclin, prostacyclin receptor (IP) and peroxisome proliferator-activated receptor (PPAR), are abundant in cardiac fibroblasts.
Yun Chen +6 more
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Recent advances in targeting the prostacyclin pathway in pulmonary arterial hypertension
European Respiratory Review, 2015 Pulmonary arterial hypertension (PAH) is a severe disease characterised by increased pulmonary vascular resistance, which leads to restricted pulmonary arterial blood flow and elevated pulmonary arterial pressure.
Irene M. Lang, Sean P. Gaine
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