Results 1 to 10 of about 47,275 (224)

In Vitro Effects of Minor Olive Oil Compounds on Prostacyclin/Thromboxane Balance Under Acute High-Glucose Conditions [PDF]

Biomolecules
This study aimed to evaluate the effects of several minor components of extra virgin olive oil (EVOO) on platelet thromboxane and vascular prostacyclin production in rat aortic rings under high-glucose conditions (300 mg/dL), in relation to their ...
Ana María Sánchez-Tévar, Laura Ortega-Hombrados, María Dolores Rodríguez-Pérez, María Monsalud Arrebola-Ramírez, Esther Martín-Aurioles, Sergio Pérez-Burillo, Cristina Verdugo-Cabello, Rocío Cobos-López, José Pedro De La Cruz, José Antonio González-Correa   +9 more
doaj   +2 more sources

Personalized allocation of acetylsalicylic acid therapy for secondary prevention of coronary artery disease

Frontiers in Cardiovascular Medicine, 2022
BackgroundA single-daily dose of 75 mg of acetylsalicylic acid inhibits 100% of thromboxane-B2 synthesis within 30–60 min. Thromboxane-B2 synthesis then recovers slowly as new platelets are released from the bone marrow.
Nischal N. Hegde, Navin Mathew, Rajesh Thachathodiyl, Jaideep C. Menon   +3 more
doaj   +1 more source

Aspirin Dosing Frequency and Dose Influence Thromboxane Suppression Despite Uniform Inhibition of Arachidonic Acid-induced Platelet Aggregation [PDF]

TH Open
John W. Eikelboom, Sonia S. Anand, Debi A. Sloane, Jack Hirsh, Huyen A. Tran, Qilong Yi, Jeffrey I. Weitz   +6 more
doaj   +2 more sources

Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility

Antioxidants, 2022
Nuclear factor erythroid factor E2-related factor 2 (Nrf2) transcribes antioxidant genes that reduce the blood pressure (BP), yet its activation with tert-butylhydroquinone (tBHQ) in mice infused with angiotensin II (Ang II) increased mean arterial ...
Dan Wang, Cheng Wang, Xueqin Hao, Gabriela Carter, Rafaela Carter, William J. Welch, Christopher S. Wilcox   +6 more
doaj   +1 more source

Impaired Clinical Efficacy of Aspirin in Hypoalbuminemic Patients With Diabetes Mellitus

Frontiers in Pharmacology, 2021
Objective: To investigate the impact of albumin levels on the aspirin efficacy, since aspirin inhibits platelet aggregation (PA) by cyclooxygenase one irreversible acetylation that is less effective in patients with type 2 diabetes mellitus (T2DM ...
Angela Sciacqua, Francesco Andreozzi, Elena Succurro, Daniele Pastori, Vittoria Cammisotto, Giuseppe Armentaro, Gaia C. Mannino, Teresa Vanessa Fiorentino, Pasquale Pignatelli, Pasquale Pignatelli, Dominick J. Angiolillo, Giorgio Sesti, Francesco Violi, Francesco Violi   +13 more
doaj   +1 more source

Urinary 11‐dehydrothromboxane B2 concentrations in 20 dogs with primary immune‐mediated hemolytic anemia

Journal of Veterinary Internal Medicine, 2022
Background Thromboembolic disease is a major cause of mortality in dogs with immune‐mediated hemolytic anemia (IMHA). At present, no reliable biomarkers of individual patient thrombotic risk are available. In human medicine, increased urinary thromboxane
Elizabeth A. Conway, Neil P. Evans, Alison E. Ridyard   +2 more
doaj   +1 more source

Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle—Implications for hypoxic pulmonary hypertension

Frontiers in Physiology, 2023
Introduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in 25% of cases.
Martha Hinton, Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala Dakshinamurti, Shyamala Dakshinamurti, Shyamala Dakshinamurti   +6 more
doaj   +1 more source

Evaluation of NTP42, a novel thromboxane receptor antagonist, in a first-in-human phase I clinical trial

Frontiers in Pharmacology, 2023
Background: The thromboxane receptor (TP) antagonist NTP42 is in clinical development for treatment of cardiopulmonary diseases, such as pulmonary arterial hypertension.
Helen M. Reid, Mark Maginn, C. Michael Perkins, Eamon P. Mulvaney, Malcolm Boyce, Takahiro Yamamoto, B. Therese Kinsella   +6 more
doaj   +1 more source

Prostanoid Metabolites as Biomarkers in Human Disease

Metabolites, 2022
Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2) together form the prostanoid family of lipid mediators. As autacoids, these five primary prostanoids propagate intercellular signals and are involved in many physiological
Helena Idborg, Sven-Christian Pawelzik
doaj   +1 more source

The state of the prostacyclin-thromboxane system in patients after aorto-coronary bypass surgery [PDF]

BIO Web of Conferences, 2023
In order to clarify the role of the prostacyclin-thromboxane system (PTS) in the development of acute circulatory disorders in the early postoperative period after coronary artery bypass surgery, its condition was studied in 86 patients with coronary ...
Kattakhanova R. Yu., Kanataeva U. N.
doaj   +1 more source