Stability of thromboxane in blood samples [PDF]
Vascular Health and Risk Management, 2019 Helga Helgadóttir,1,2 Ísleifur Ólafsson,2 Karl Andersen,3 Sveinbjörn Gizurarson11Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland; 2Department of Clinical Biochemistry, Landspitali University ...
Helgadóttir H +3 more
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Thromboxane Biosynthesis and its Inhibition in Man [PDF]
, 1987 The principal product of arachidonic acid in the platelet is thromboxane A2 This compound is the most potent endogenous platelet agonist and vasoconstrictor known in man.
Reilly, Irene A. G
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Development of Methodology for the Measurement of Prostacyclin and Thromboxane Production: Possible Relevance of Prostacyclin/Thromboxane Balance in Clinical Conditions [PDF]
, 1986 This thesis describes the historical development of our knowledge of prostaglandins and thromboxane and the synthesis, metabolism and actions of prostacyclin and thromboxane.
McLaren, Margaret
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Current status and future perspectives of platelet function-guided precision antiplatelet therapy for patients with cerebral infarction. [PDF]
NeuroprotectionAntiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Zhu G +7 more
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Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Thromboxane and the thromboxane receptor in cardiovascular disease [PDF]
Clinical Lipidology, 2010 Thromboxane A(2) (TXA(2)), the primary product of COX-1-dependent metabolism of arachidonic acid, mediates its biological actions through the TXA(2) receptor, termed the TP. Irreversible inhibition of platelet COX-1-derived TXA(2) with low-dose aspirin affords protection against primary and secondary vascular thrombotic events, underscoring the central
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Prostanoids and Resolution of Inflammation – Beyond the Lipid-Mediator Class Switch
Frontiers in Immunology, 2021 Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein, early pro-inflammatory phases are characterized and regulated by prostanoids and leukotrienes, whereas specialized pro-resolving mediators (SPM), including lipoxins,
Tobias Schmid +4 more
doaj +1 more source
Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers [PDF]
, 2003 Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA).
Zöllner, N., Adam, Olaf, Wolfram, G.
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Thromboxane Mobilizes Insect Blood Cells to Infection Foci
Frontiers in Immunology, 2021 Innate immune responses are effective for insect survival to defend against entomopathogens including a fungal pathogen, Metarhizium rileyi, that infects a lepidopteran Spodoptera exigua.
Miltan Chandra Roy +4 more
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