Results 31 to 40 of about 47,275 (224)

Differential Impact of Serial Measurement of Nonplatelet Thromboxane Generation on Long‐Term Outcome After Cardiac Surgery

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSystemic thromboxane generation, not suppressible by standard aspirin therapy and likely arising from nonplatelet sources, increases the risk of atherothrombosis and death in patients with cardiovascular disease.
Nikolaos Kakouros, Tyler J. Gluckman, John V. Conte, Thomas S. Kickler, Katherine Laws, Bruce A. Barton, Jeffrey J. Rade   +6 more
doaj   +1 more source

Increased Thromboxane A₂ Levels in Pulmonary Artery Smooth Muscle Cells Isolated from Patients with Chronic Obstructive Pulmonary Disease

Medicina, 2023
Introduction: Pulmonary hypertension due to chronic obstructive pulmonary disease (COPD) is classified as Group 3 pulmonary hypertension, with no current proven targeted therapies.
Abdullah A. Alqarni
doaj   +1 more source

Prostaglandins in Marine Organisms: A Review

Marine Drugs, 2019
Prostaglandins (PGs) are lipid mediators belonging to the eicosanoid family. PGs were first discovered in mammals where they are key players in a great variety of physiological and pathological processes, for instance muscle and blood vessel tone ...
Federica Di Costanzo, Valeria Di Dato, Adrianna Ianora, Giovanna Romano   +3 more
doaj   +1 more source

Eupatilin Alleviates Acute Myocardial Ischemia-Reperfusion Injury in Rats via the Akt/GSK-3β Pathway by Targeting COXs. [PDF]

J Biochem Mol Toxicol
It has been reported that eupatilin exerts cardioprotective effects after myocardial ischemia‐reperfusion injury (MIRI). This study further found that Eupatilin alleviated acute MIRI in rats by specifically inhibiting cyclooxygenase enzymes (COXs) and activating the Akt/GSK‐3β pathway, providing a theoretical basis for the application of eupatilin in ...
Guo M, Li Q, Ji L.
europepmc   +2 more sources

Thromboxane metabolite data

, 2023
The establishment of reference interval in 333 healthy adults provides a reference for diseases related to platelet activation and the use of drugs, and the first discovery of the correlation between 11-dehydro-thromboxane B2 and 11-dehydro-2, 3-dinor ...
Furong Zhao (17182909)
core   +1 more source

Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis

Respiratory Research, 2002
Background Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), we hypothesized that ...
Pierson Richard, Loyd James E, Lane Kirk B, Dworski Ryszard, Stecenko Arlene A, Cruz-Gervis Roberto, King Gayle, Brigham Kenneth L   +7 more
doaj   +1 more source

Expression changes of prostacyclin and thromboxane in blood of rats with tail vibration

环境与职业医学, 2022
BackgroundLong-term exposure to hand-transmitted vibration can lead to hand-arm vibration syndrome, one manifestation of which is impaired peripheral blood circulation in the arms.
Ziyu CHEN, Nuoyan WEI, Zhishan LIANG, Huimin HUANG, Xiuwen HU, Junyi WANG, Qingsong CHEN, Hongyu YANG   +7 more
doaj   +1 more source

Role of mast cell- and non-mast cell-derived inflammatory mediators in immunologic induction of synaptic plasticity

Brazilian Journal of Medical and Biological Research, 1997
We have previously discovered a long-lasting enhancement of synaptic transmission in mammal autonomic ganglia caused by immunological activation of ganglionic mast cells.
A.A.C. Albuquerque, J.H. Leal-Cardoso, D. Weinreich   +2 more
doaj   +1 more source

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling

Haematologica, 2020
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 is expressed in human
Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins   +15 more
doaj   +1 more source

Cyclooxygenase inhibitors blunt thromboxane action in human placental arteries by blocking thromboxane receptors

, 1992
The effects of cyclooxygenase inhibitors on thromboxane-mediated vasoconstriction in human placental arteries were studied in the isolated perfused fetoplacental cotyledon.
S. Y. Sung, P. F. Mento, B. M. Wilkes, A. M. Hollander   +3 more
core   +1 more source