Results 51 to 60 of about 47,275 (224)

New developments on thromboxane and prostacyclin modulators - Part I: Thromboxane modulators

, 2004
The pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases can be related to arachidonic acid (AA) metabolites. One of these bioactive metabolites of particular importance is thromboxane A2 (TXA2). It is produced by
Dogne, JM, Ghuysen, A, Lambermont, B, Hanson, J, Casini, Angela, Ruan, KH, Kolh, P, de Leval, X, Masereel, B, Pirotte, B, Frederich, M   +10 more
core   +5 more sources

Effects of combined therapy with atorvastatin and polyunsaturated omega-3 fatty acids on lipid profile, lipoprotein-associated phospholipase A2 and thromboxane

Кардиоваскулярная терапия и профилактика, 2010
Aim. To study the effects of the combined therapy with atorvastatin and polyunsaturated omega-3 fatty acids (omega-3 PUFA) on lipid profile, lipoprotein-associated phospholipase A2 (Lp-PLA (2)), and thromboxane B2. Material and methods.
G. F. Piksina, Yu. A. Shuvalova, V. I. Kaminnaya, Yu. V. Dotsenko, V. N. Titov, V. V. Kukharchuk, A. I. Kaminny   +6 more
doaj  

Is Less More? An Update on Aspirin for Cancer Prevention in Lynch Syndrome From the Cancer Prevention Programme—CaPP

International Journal of Cancer, EarlyView.
ABSTRACT Aspirin has been used to treat pain and fever for 120 years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti‐cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials.
John Burn, D. Timothy Bishop
wiley   +1 more source

Thromboxane-prostacyclin balance and platelet aggregability in patients with minor cardiac abnormalities

Терапевтический архив, 2010
Aim. To reveal changes in the thromboxane-prostacyclin balance and platelet aggregability in patients with various variants of minor cardiac abnormalities. Subjects and methods: Six-five patients (mean age 23.0±0.7 years) with minor cardiac abnormalities
Aleksandr Valentinovich Yagoda, Natal'ya Nikolaevna Gladkikh, A V Yagoda, N N Gladkikh   +3 more
doaj  

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

, 2000
Terbogrel, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hair-pin like conformation stabilized by an intramolecular hydrogen bond.
Delarge, Jacques, Norberg, Bernadette, Wouters, Johan; id_orcid, Michaux, Catherine; id_orcid, Masereel, Bernard, Dogné, Jean-Michel, Durant, François   +6 more
core   +1 more source

Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men

Artery Research, 2018
Background: Reduction in central arterial compliance is an independent risk factor for cardiovascular disease, and is caused by high-intensity resistance training.
Kaname Tagawa, Song-Gyu Ra, Hiroshi Kumagai, Yuriko Sawano, Kosaku Yamamoto, Toru Yoshikawa, Youngju Choi, Yasuko Yoshida, Kazuhiro Takekoshi, Seiji Maeda   +9 more
doaj   +1 more source

Aspirin Reduces the Potentiating Effect of CD40L on Platelet Aggregation via Inhibition of Myosin Light Chain

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Antiplatelet therapy with aspirin (acetylsalicylic acid [ASA]) is less efficient in some coronary patients, which increases their risk of developing thrombosis. Elevated blood levels of thromboinflammatory mediators, like soluble CD40L (sCD40L)
Kevin Kojok, Mira Mohsen, Abed El Hakim El Kadiry, Walid Mourad, Yahye Merhi   +4 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source